ZNF521 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048663Biological processneuron fate commitment
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0019904Molecular functionprotein domain specific binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNF521
Protein nameZinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3)
ZNF521 protein
Zinc finger protein 521
SynonymsLIP3
EHZF
DescriptionFUNCTION: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. .

AccessionsENST00000584787.5
ENST00000577801.5
ENST00000577775.1
H7BYU6
J3QRW6
Q96K83
ENST00000361524.8
ENST00000580488.1
ENST00000399425.6
J3QQI2
J3KT07
Q8IYZ2
J3KSZ4
J3KTI4
ENST00000577461.1
ENST00000538137.6