ZIC2 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	3 studies	26% ± 11%	Explore
granule cell	3 studies	36% ± 11%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZIC2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	4188.42	2608 / 2642	99%	13.46	697 / 705
tonsil	0%	0	0 / 0	91%	19.05	41 / 45
esophagus	1%	0.63	10 / 1445	70%	8.96	128 / 183
uterus	1%	0.54	1 / 170	70%	14.85	321 / 459
liver	0%	0.32	1 / 226	57%	5.70	233 / 406
prostate	0%	0.34	1 / 245	54%	4.44	273 / 502
lung	1%	2.93	6 / 578	54%	6.49	618 / 1155
bladder	0%	0	0 / 21	44%	6.06	221 / 504
intestine	0%	0	0 / 966	43%	7.22	229 / 527
stomach	0%	0	0 / 359	40%	5.05	113 / 286
breast	2%	2.38	11 / 459	32%	2.55	358 / 1118
ovary	2%	5.34	3 / 180	29%	10.44	125 / 430
pancreas	0%	0.51	1 / 328	26%	1.76	46 / 178
skin	1%	1.13	21 / 1809	18%	1.56	87 / 472
lymph node	0%	0	0 / 0	14%	1.02	4 / 29
adrenal gland	1%	52.70	2 / 258	9%	0.55	21 / 230
kidney	1%	1.18	1 / 89	5%	0.72	44 / 901
eye	0%	0	0 / 0	3%	0.10	2 / 80
thymus	0%	0.34	3 / 653	1%	0.10	6 / 605
adipose	1%	1.05	12 / 1204	0%	0	0 / 0
heart	0%	0.34	2 / 861	0%	0	0 / 0
blood vessel	0%	0.50	3 / 1335	0%	0	0 / 0
muscle	0%	0.09	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007420	Biological process	brain development
GO_0007601	Biological process	visual perception
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0007417	Biological process	central nervous system development
GO_0030154	Biological process	cell differentiation
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0016604	Cellular component	nuclear body
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0031490	Molecular function	chromatin DNA binding
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872	Molecular function	metal ion binding

Gene name	ZIC2
Protein name	Zinc finger protein ZIC 2 (Zinc finger protein of the cerebellum 2)
Synonyms
Description	FUNCTION: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
Accessions	ENST00000376335.8 O95409

ZIC2 report