ZIC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008589Biological processregulation of smoothened signaling pathway
GO_0007628Biological processadult walking behavior
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0021766Biological processhippocampus development
GO_0021510Biological processspinal cord development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0021772Biological processolfactory bulb development
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0007417Biological processcentral nervous system development
GO_0042472Biological processinner ear morphogenesis
GO_0007420Biological processbrain development
GO_0098727Biological processmaintenance of cell number
GO_0010467Biological processgene expression
GO_0007389Biological processpattern specification process
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZIC1
Protein nameZic family member 1
Zinc finger protein ZIC 1 (Zinc finger protein 201) (Zinc finger protein of the cerebellum 1)
SynonymsZIC
ZNF201
DescriptionFUNCTION: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). .

AccessionsH7C5D8
ENST00000488404.5
ENST00000282928.5
Q15915