ZFYVE9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016197Biological processendosomal transport
GO_0006897Biological processendocytosis
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031901Cellular componentearly endosome membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005769Cellular componentearly endosome
GO_0005545Molecular function1-phosphatidylinositol binding
GO_0019904Molecular functionprotein domain specific binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZFYVE9
Protein nameAlternative protein ZFYVE9
Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)
SynonymsMADHIP
SMADIP
SARA
DescriptionFUNCTION: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. .

AccessionsL8E993
O95405
ENST00000371591.2 [O95405-1]
L8ECB6
ENST00000357206.6 [O95405-2]
ENST00000287727.8 [O95405-1]