ZFAND2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045047Biological processprotein targeting to ER
GO_0006616Biological processSRP-dependent cotranslational protein targeting to membrane, translocation
GO_0043567Biological processregulation of insulin-like growth factor receptor signaling pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502Cellular componentproteasome complex
GO_0005737Cellular componentcytoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0036435Molecular functionK48-linked polyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameZFAND2B
Protein nameAN1-type zinc finger protein 2B (Arsenite-inducible RNA-associated protein-like protein) (AIRAP-like protein)
Zinc finger, AN1-type domain 2B, isoform CRA_c (cDNA FLJ90090 fis, clone HEMBA1005430, highly similar to AN1-type zinc finger protein 2B)
Zinc finger AN1-type containing 2B (cDNA FLJ60439, highly similar to AN1-type zinc finger protein 2B)
Zinc finger AN1-type containing 2B
SynonymsAIRAPL
hCG_1780765
DescriptionFUNCTION: Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway . .

AccessionsQ8WV99
ENST00000409206.5 [Q8WV99-2]
ENST00000409217.5
ENST00000409097.5
C9J1R6
H7C491
E9PFU9
ENST00000444522.6 [Q8WV99-1]
ENST00000409594.5 [Q8WV99-2]
ENST00000422255.5
ENST00000409336.5 [Q8WV99-1]
ENST00000621130.4
ENST00000409412.5
ENST00000289528.10 [Q8WV99-1]
B4DEN4
ENST00000448496.5
ENST00000436556.5
ENST00000409319.5
F8WEE4
ENST00000425849.1
B8ZZ56
B3KQB0
E7EV05
A0A087X0D9