ZFAND1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034599Biological processcellular response to oxidative stress
GO_0035617Biological processstress granule disassembly
GO_1903843Biological processcellular response to arsenite ion
GO_0071470Biological processcellular response to osmotic stress
GO_0034605Biological processcellular response to heat
GO_0090316Biological processpositive regulation of intracellular protein transport
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005737Cellular componentcytoplasm
GO_0070628Molecular functionproteasome binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameZFAND1
Protein nameAN1-type zinc finger protein 1 (Zinc finger AN1-type-containing protein 1)
ZFAND1 protein (Zinc finger, AN1-type domain 1, isoform CRA_d) (cDNA FLJ52833, highly similar to AN1-type zinc finger protein 1)
Zinc finger AN1-type containing 1
SynonymshCG_21305
DescriptionFUNCTION: Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress . Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome . This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy . .

AccessionsE5RG60
ENST00000521287.5 [Q8TCF1-2]
E5RIH7
ENST00000520635.5
E5RFU1
E5RJ74
ENST00000220669.10 [Q8TCF1-1]
ENST00000523361.5
ENST00000517588.5
E5RI74
ENST00000519523.5 [Q8TCF1-4]
Q8TCF1
ENST00000522032.1
ENST00000518419.5
ENST00000523096.5 [Q8TCF1-3]
E5RGE5
E5RFE5
ENST00000519464.5
ENST00000521895.5
ENST00000523431.5
Q05BD2
E5RK75
ENST00000522520.5 [Q8TCF1-2]
ENST00000517450.5
ENST00000521742.5
ENST00000520604.5
ENST00000520076.5
E5RHR9
H0YBX7
E5RIS3