Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 12 studies | 26% ± 9% | |
adipocyte | 9 studies | 23% ± 6% | |
astrocyte | 9 studies | 32% ± 14% | |
oligodendrocyte | 9 studies | 29% ± 10% | |
glutamatergic neuron | 7 studies | 44% ± 27% | |
microglial cell | 7 studies | 26% ± 7% | |
fibroblast | 7 studies | 23% ± 5% | |
GABAergic neuron | 7 studies | 39% ± 22% | |
oligodendrocyte precursor cell | 7 studies | 29% ± 13% | |
retinal cone cell | 5 studies | 44% ± 16% | |
cardiac muscle cell | 5 studies | 33% ± 6% | |
epithelial cell | 5 studies | 24% ± 13% | |
endothelial cell of lymphatic vessel | 5 studies | 24% ± 7% | |
T cell | 5 studies | 19% ± 2% | |
macrophage | 5 studies | 30% ± 6% | |
type I pneumocyte | 5 studies | 31% ± 10% | |
interneuron | 5 studies | 41% ± 24% | |
retinal rod cell | 4 studies | 22% ± 6% | |
pericyte | 4 studies | 22% ± 6% | |
smooth muscle cell | 4 studies | 20% ± 1% | |
neuron | 3 studies | 31% ± 13% | |
GABAergic interneuron | 3 studies | 18% ± 2% | |
plasma cell | 3 studies | 25% ± 4% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 18% ± 2% | |
amacrine cell | 3 studies | 18% ± 4% | |
B cell | 3 studies | 18% ± 2% | |
dendritic cell | 3 studies | 20% ± 5% | |
alveolar macrophage | 3 studies | 22% ± 7% | |
monocyte | 3 studies | 22% ± 5% | |
lymphocyte | 3 studies | 25% ± 8% | |
transit amplifying cell | 3 studies | 34% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1921.14 | 1445 / 1445 | 100% | 18.01 | 183 / 183 |
stomach | 100% | 1529.30 | 359 / 359 | 100% | 17.32 | 286 / 286 |
breast | 100% | 2149.19 | 459 / 459 | 100% | 12.82 | 1116 / 1118 |
intestine | 100% | 2009.29 | 966 / 966 | 100% | 15.88 | 526 / 527 |
lung | 100% | 2000.73 | 577 / 578 | 100% | 10.31 | 1154 / 1155 |
prostate | 100% | 1811.29 | 245 / 245 | 100% | 9.20 | 500 / 502 |
bladder | 100% | 2086.71 | 21 / 21 | 99% | 11.25 | 501 / 504 |
thymus | 100% | 2098.70 | 653 / 653 | 99% | 9.21 | 601 / 605 |
ovary | 100% | 2185.86 | 180 / 180 | 99% | 7.42 | 427 / 430 |
pancreas | 100% | 1257.11 | 327 / 328 | 99% | 8.19 | 177 / 178 |
uterus | 100% | 2283.03 | 170 / 170 | 99% | 9.92 | 455 / 459 |
brain | 98% | 1337.73 | 2599 / 2642 | 100% | 10.52 | 705 / 705 |
skin | 100% | 2531.13 | 1809 / 1809 | 98% | 15.36 | 464 / 472 |
kidney | 100% | 1273.37 | 89 / 89 | 98% | 9.06 | 882 / 901 |
adrenal gland | 100% | 1658.27 | 258 / 258 | 94% | 6.64 | 216 / 230 |
liver | 100% | 893.94 | 226 / 226 | 88% | 4.48 | 358 / 406 |
adipose | 100% | 2124.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1786.77 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 9.74 | 29 / 29 |
muscle | 100% | 7459.05 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2032.00 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 11.28 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.71 | 1 / 1 |
heart | 97% | 1742.47 | 839 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 93% | 7.85 | 74 / 80 |
peripheral blood | 54% | 1282.36 | 506 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0046827 | Biological process | positive regulation of protein export from nucleus |
GO_0006611 | Biological process | protein export from nucleus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005643 | Cellular component | nuclear pore |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005049 | Molecular function | nuclear export signal receptor activity |
GO_0005515 | Molecular function | protein binding |
GO_0031267 | Molecular function | small GTPase binding |
Gene name | XPO4 |
Protein name | Exportin-4 (Exp4) XPO4 protein Exportin-4 |
Synonyms | KIAA1721 |
Description | FUNCTION: Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) . In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins . Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor . XPO4 then return to the nuclear compartment and mediate another round of transport . The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus . Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 . Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 . Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (By similarity). . |
Accessions | Q9C0E2 Q86VC1 Q0VG75 Q8IVQ8 ENST00000255305.11 |