XPO4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046827Biological processpositive regulation of protein export from nucleus
GO_0006611Biological processprotein export from nucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005643Cellular componentnuclear pore
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005049Molecular functionnuclear export signal receptor activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameXPO4
Protein nameExportin-4 (Exp4)
XPO4 protein
Exportin-4
SynonymsKIAA1721
DescriptionFUNCTION: Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) . In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins . Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor . XPO4 then return to the nuclear compartment and mediate another round of transport . The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus . Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 . Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 . Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (By similarity). .

AccessionsQ9C0E2
Q86VC1
Q0VG75
Q8IVQ8
ENST00000255305.11