WDR45B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000422Biological processautophagy of mitochondrion
GO_0030242Biological processautophagy of peroxisome
GO_0009267Biological processcellular response to starvation
GO_0061723Biological processglycophagy
GO_0044804Biological processnucleophagy
GO_0000045Biological processautophagosome assembly
GO_0006497Biological processprotein lipidation
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0034045Cellular componentphagophore assembly site membrane
GO_0005764Cellular componentlysosome
GO_0005829Cellular componentcytosol
GO_0019898Cellular componentextrinsic component of membrane
GO_0000407Cellular componentphagophore assembly site
GO_0062078Molecular functionTSC1-TSC2 complex binding
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWDR45B
Protein nameWD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein)
WD repeat domain 45B
SynonymsWDR45L
WIPI3
DescriptionFUNCTION: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation . Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 . In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway . .

AccessionsQ5MNZ6
I3L3A5
I3L4L8
ENST00000576517.1
I3L4S6
ENST00000572583.5
I3L1D0
ENST00000571817.5
ENST00000392325.9
ENST00000573616.5