WDR11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008589Biological processregulation of smoothened signaling pathway
GO_0060271Biological processcilium assembly
GO_0099041Biological processvesicle tethering to Golgi
GO_0035264Biological processmulticellular organism growth
GO_0006886Biological processintracellular protein transport
GO_0060322Biological processhead development
GO_0007507Biological processheart development
GO_0005930Cellular componentaxoneme
GO_0005802Cellular componenttrans-Golgi network
GO_0036064Cellular componentciliary basal body
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005765Cellular componentlysosomal membrane
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWDR11
Protein nameWD repeat domain 11
WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15)
SynonymsBRWD2
KIAA1351
WDR15
DescriptionFUNCTION: Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis . Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production . WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 . .

AccessionsS4R3Z0
S4R3P9
Q9BZH6
ENST00000497136.6
ENST00000605543.5
ENST00000604585.5
S4R451
ENST00000263461.11