Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 37 studies | 34% ± 13% | |
| non-classical monocyte | 24 studies | 61% ± 15% | |
| classical monocyte | 21 studies | 30% ± 12% | |
| monocyte | 19 studies | 33% ± 11% | |
| endothelial cell of lymphatic vessel | 18 studies | 32% ± 9% | |
| conventional dendritic cell | 18 studies | 32% ± 12% | |
| capillary endothelial cell | 14 studies | 40% ± 13% | |
| macrophage | 13 studies | 25% ± 8% | |
| endothelial cell of artery | 13 studies | 30% ± 11% | |
| dendritic cell | 11 studies | 30% ± 16% | |
| endothelial cell of vascular tree | 10 studies | 28% ± 13% | |
| ciliated cell | 9 studies | 25% ± 9% | |
| vein endothelial cell | 9 studies | 29% ± 11% | |
| plasma cell | 8 studies | 36% ± 15% | |
| myeloid cell | 7 studies | 27% ± 9% | |
| fibroblast | 6 studies | 23% ± 7% | |
| plasmablast | 4 studies | 50% ± 24% | |
| epithelial cell | 4 studies | 32% ± 13% | |
| plasmacytoid dendritic cell | 4 studies | 20% ± 5% | |
| mononuclear phagocyte | 3 studies | 28% ± 10% | |
| glomerular endothelial cell | 3 studies | 38% ± 1% | |
| natural killer cell | 3 studies | 27% ± 15% | |
| secretory cell | 3 studies | 25% ± 6% | |
| GABAergic neuron | 3 studies | 29% ± 11% | |
| glutamatergic neuron | 3 studies | 38% ± 15% | |
| connective tissue cell | 3 studies | 24% ± 10% | |
| alveolar macrophage | 3 studies | 22% ± 1% | |
| astrocyte | 3 studies | 20% ± 2% | |
| IgA plasma cell | 3 studies | 18% ± 1% | |
| CD4-positive, alpha-beta T cell | 3 studies | 34% ± 13% | |
| CD8-positive, alpha-beta T cell | 3 studies | 27% ± 13% | |
| regulatory T cell | 3 studies | 32% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 21736.40 | 578 / 578 | 99% | 141.54 | 1146 / 1155 |
| thymus | 100% | 7510.68 | 653 / 653 | 99% | 172.78 | 596 / 605 |
| skin | 99% | 5243.60 | 1789 / 1809 | 99% | 499.61 | 468 / 472 |
| esophagus | 100% | 5378.41 | 1441 / 1445 | 98% | 130.62 | 179 / 183 |
| intestine | 100% | 6038.89 | 966 / 966 | 97% | 100.69 | 510 / 527 |
| stomach | 100% | 4783.87 | 359 / 359 | 96% | 131.04 | 275 / 286 |
| uterus | 100% | 4158.98 | 170 / 170 | 96% | 165.76 | 441 / 459 |
| breast | 100% | 7167.63 | 458 / 459 | 96% | 77.62 | 1072 / 1118 |
| prostate | 100% | 5284.03 | 244 / 245 | 96% | 50.17 | 481 / 502 |
| pancreas | 95% | 2731.41 | 313 / 328 | 92% | 74.84 | 164 / 178 |
| bladder | 100% | 5601.81 | 21 / 21 | 86% | 124.51 | 432 / 504 |
| kidney | 100% | 6238.04 | 89 / 89 | 85% | 59.06 | 763 / 901 |
| brain | 95% | 4022.89 | 2508 / 2642 | 86% | 52.89 | 608 / 705 |
| adrenal gland | 100% | 6874.19 | 258 / 258 | 77% | 43.70 | 178 / 230 |
| ovary | 86% | 2116.01 | 155 / 180 | 91% | 70.79 | 392 / 430 |
| liver | 77% | 2188.54 | 173 / 226 | 34% | 18.81 | 137 / 406 |
| adipose | 100% | 9376.98 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 283.83 | 29 / 29 |
| spleen | 100% | 9794.72 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 232.00 | 45 / 45 |
| heart | 100% | 6950.79 | 860 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 4391.87 | 1327 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 4384.12 | 798 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 97% | 10892.31 | 899 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 93% | 260.40 | 74 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0006469 | Biological process | negative regulation of protein kinase activity |
| GO_0006412 | Biological process | translation |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0045765 | Biological process | regulation of angiogenesis |
| GO_0031334 | Biological process | positive regulation of protein-containing complex assembly |
| GO_0006436 | Biological process | tryptophanyl-tRNA aminoacylation |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0019904 | Molecular function | protein domain specific binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0019210 | Molecular function | kinase inhibitor activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004830 | Molecular function | tryptophan-tRNA ligase activity |
| Gene name | WARS1 |
| Protein name | Tryptophanyl-tRNA synthetase Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS] tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) Tryptophanyl-tRNA synthetase 1 |
| Synonyms | WARS IFI53 WRS |
| Description | FUNCTION: Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). .; FUNCTION: [Isoform 1]: Has no angiostatic activity. .; FUNCTION: [T2-TrpRS]: Possesses an angiostatic activity but has no aminoacylation activity . Inhibits fluid shear stress-activated responses of endothelial cells . Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression . .; FUNCTION: [Isoform 2]: Has an angiostatic activity. . |
| Accessions | ENST00000554509.5 ENST00000554820.5 ENST00000556435.5 G3V3H8 G3V2F2 G3V3S7 G3V3X0 ENST00000556695.5 P78534 ENST00000553395.5 ENST00000358655.8 [P23381-2] G3V5U1 ENST00000555410.5 ENST00000553545.5 G3V5W1 ENST00000557297.5 G3V2Y7 ENST00000554772.5 G3V339 ENST00000627608.1 ENST00000553524.5 ENST00000556209.5 G3V2C0 G3V5H5 P23381 ENST00000553934.1 ENST00000553581.1 G3V227 G3V423 ENST00000553413.5 ENST00000555031.5 ENST00000556660.5 ENST00000344102.9 [P23381-2] G3V456 ENST00000555813.5 ENST00000556338.5 ENST00000392882.7 [P23381-1] H0YJP3 ENST00000556504.5 G3V3R3 G3V4A3 G3V3P2 ENST00000557347.5 G3V4S4 ENST00000553769.6 ENST00000554605.5 G3V4N0 ENST00000355338.6 [P23381-1] ENST00000557722.5 ENST00000556295.5 G3V313 ENST00000554601.1 G3V277 G3V3Y5 G3V4C7 G3V4N8 G3V4Q0 ENST00000557135.5 [P23381-1] ENST00000556698.5 ENST00000556783.5 ENST00000556645.5 [P23381-2] |