WARS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0006412Biological processtranslation
GO_0010628Biological processpositive regulation of gene expression
GO_0045765Biological processregulation of angiogenesis
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0006436Biological processtryptophanyl-tRNA aminoacylation
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0019904Molecular functionprotein domain specific binding
GO_0019901Molecular functionprotein kinase binding
GO_0019210Molecular functionkinase inhibitor activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0004830Molecular functiontryptophan-tRNA ligase activity

IV. Literature review

[source]
Gene nameWARS1
Protein nameTryptophanyl-tRNA synthetase
Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]
tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase)
Tryptophanyl-tRNA synthetase 1
SynonymsWARS
IFI53
WRS
DescriptionFUNCTION: Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). .; FUNCTION: [Isoform 1]: Has no angiostatic activity. .; FUNCTION: [T2-TrpRS]: Possesses an angiostatic activity but has no aminoacylation activity . Inhibits fluid shear stress-activated responses of endothelial cells . Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression . .; FUNCTION: [Isoform 2]: Has an angiostatic activity. .

AccessionsENST00000554509.5
ENST00000554820.5
ENST00000556435.5
G3V3H8
G3V2F2
G3V3S7
G3V3X0
ENST00000556695.5
P78534
ENST00000553395.5
ENST00000358655.8 [P23381-2]
G3V5U1
ENST00000555410.5
ENST00000553545.5
G3V5W1
ENST00000557297.5
G3V2Y7
ENST00000554772.5
G3V339
ENST00000627608.1
ENST00000553524.5
ENST00000556209.5
G3V2C0
G3V5H5
P23381
ENST00000553934.1
ENST00000553581.1
G3V227
G3V423
ENST00000553413.5
ENST00000555031.5
ENST00000556660.5
ENST00000344102.9 [P23381-2]
G3V456
ENST00000555813.5
ENST00000556338.5
ENST00000392882.7 [P23381-1]
H0YJP3
ENST00000556504.5
G3V3R3
G3V4A3
G3V3P2
ENST00000557347.5
G3V4S4
ENST00000553769.6
ENST00000554605.5
G3V4N0
ENST00000355338.6 [P23381-1]
ENST00000557722.5
ENST00000556295.5
G3V313
ENST00000554601.1
G3V277
G3V3Y5
G3V4C7
G3V4N8
G3V4Q0
ENST00000557135.5 [P23381-1]
ENST00000556698.5
ENST00000556783.5
ENST00000556645.5 [P23381-2]