Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 34% ± 18% | |
astrocyte | 11 studies | 33% ± 16% | |
macrophage | 11 studies | 30% ± 13% | |
oligodendrocyte | 11 studies | 31% ± 12% | |
glutamatergic neuron | 10 studies | 48% ± 26% | |
microglial cell | 10 studies | 30% ± 11% | |
oligodendrocyte precursor cell | 10 studies | 33% ± 14% | |
GABAergic neuron | 8 studies | 40% ± 23% | |
neuron | 6 studies | 29% ± 13% | |
interneuron | 6 studies | 43% ± 21% | |
epithelial cell | 6 studies | 35% ± 13% | |
fibroblast | 6 studies | 24% ± 13% | |
myeloid cell | 5 studies | 25% ± 7% | |
dendritic cell | 5 studies | 23% ± 5% | |
type II pneumocyte | 5 studies | 21% ± 7% | |
monocyte | 5 studies | 24% ± 5% | |
amacrine cell | 4 studies | 25% ± 6% | |
retinal pigment epithelial cell | 4 studies | 32% ± 10% | |
endothelial cell of lymphatic vessel | 4 studies | 25% ± 3% | |
mast cell | 4 studies | 22% ± 4% | |
classical monocyte | 3 studies | 18% ± 2% | |
GABAergic interneuron | 3 studies | 26% ± 6% | |
granule cell | 3 studies | 19% ± 1% | |
retinal ganglion cell | 3 studies | 28% ± 9% | |
ciliated cell | 3 studies | 23% ± 2% | |
lymphocyte | 3 studies | 22% ± 6% | |
GABAergic amacrine cell | 3 studies | 32% ± 9% | |
hepatocyte | 3 studies | 29% ± 10% | |
connective tissue cell | 3 studies | 18% ± 3% | |
ependymal cell | 3 studies | 29% ± 12% | |
club cell | 3 studies | 21% ± 8% | |
alveolar macrophage | 3 studies | 36% ± 10% | |
type I pneumocyte | 3 studies | 22% ± 7% | |
basal cell | 3 studies | 33% ± 23% | |
goblet cell | 3 studies | 26% ± 13% | |
adipocyte | 3 studies | 21% ± 1% | |
smooth muscle cell | 3 studies | 18% ± 0% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 4192.57 | 2642 / 2642 | 100% | 48.74 | 705 / 705 |
esophagus | 100% | 2784.54 | 1445 / 1445 | 100% | 27.96 | 183 / 183 |
lung | 100% | 2951.90 | 578 / 578 | 100% | 30.05 | 1155 / 1155 |
prostate | 100% | 3087.87 | 245 / 245 | 100% | 29.69 | 502 / 502 |
breast | 100% | 2857.60 | 459 / 459 | 100% | 31.80 | 1116 / 1118 |
bladder | 100% | 3040.10 | 21 / 21 | 100% | 24.76 | 503 / 504 |
ovary | 100% | 3866.24 | 180 / 180 | 100% | 18.96 | 429 / 430 |
kidney | 100% | 2647.33 | 89 / 89 | 100% | 30.79 | 898 / 901 |
stomach | 100% | 2218.18 | 359 / 359 | 100% | 24.20 | 285 / 286 |
intestine | 100% | 2938.66 | 966 / 966 | 100% | 23.93 | 525 / 527 |
uterus | 100% | 3202.09 | 170 / 170 | 100% | 22.15 | 457 / 459 |
thymus | 100% | 3012.23 | 653 / 653 | 100% | 27.90 | 602 / 605 |
skin | 100% | 3346.02 | 1808 / 1809 | 99% | 41.69 | 467 / 472 |
pancreas | 99% | 1906.80 | 326 / 328 | 99% | 30.74 | 177 / 178 |
adrenal gland | 100% | 3174.26 | 258 / 258 | 98% | 30.08 | 225 / 230 |
liver | 100% | 1351.04 | 225 / 226 | 96% | 15.46 | 388 / 406 |
adipose | 100% | 2968.39 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3960.20 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 25.78 | 29 / 29 |
spleen | 100% | 3137.32 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 19.71 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.68 | 1 / 1 |
heart | 96% | 1928.44 | 830 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 29.42 | 77 / 80 |
peripheral blood | 91% | 2133.29 | 846 / 929 | 0% | 0 | 0 / 0 |
muscle | 89% | 821.41 | 713 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006623 | Biological process | protein targeting to vacuole |
GO_0016236 | Biological process | macroautophagy |
GO_0009267 | Biological process | cellular response to starvation |
GO_0016192 | Biological process | vesicle-mediated transport |
GO_0008333 | Biological process | endosome to lysosome transport |
GO_1902774 | Biological process | late endosome to lysosome transport |
GO_0035542 | Biological process | regulation of SNARE complex assembly |
GO_0034058 | Biological process | endosomal vesicle fusion |
GO_0031902 | Cellular component | late endosome membrane |
GO_0030897 | Cellular component | HOPS complex |
GO_1902501 | Cellular component | lysosomal HOPS complex |
GO_0031901 | Cellular component | early endosome membrane |
GO_0005764 | Cellular component | lysosome |
GO_0030136 | Cellular component | clathrin-coated vesicle |
GO_0071439 | Cellular component | clathrin complex |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0030123 | Cellular component | AP-3 adaptor complex |
GO_0005829 | Cellular component | cytosol |
GO_0015630 | Cellular component | microtubule cytoskeleton |
GO_0005770 | Cellular component | late endosome |
GO_0010008 | Cellular component | endosome membrane |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0042802 | Molecular function | identical protein binding |
GO_0008017 | Molecular function | microtubule binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | VPS41 |
Protein name | Vacuolar protein sorting-associated protein 41 homolog (S53) VPS41 subunit of HOPS complex Uncharacterized protein VPS41 Vacuolar protein sorting-associated protein 41 homolog |
Synonyms | |
Description | FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes . Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo . Required for fusion of autophagosomes with lysosomes . Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion . Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS . Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway . . FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. . |
Accessions | ENST00000448833.5 H7BZX6 H7BXH3 ENST00000439468.1 Q75MX9 P49754 ENST00000457055.1 C9J2U9 ENST00000395969.6 [P49754-3] ENST00000413141.5 C9J3F8 H7C0K2 ENST00000414632.5 ENST00000418457.6 Q75MS1 Q75MS2 ENST00000265745.13 ENST00000310301.9 [P49754-1] C9JU58 C9JZ11 |