VPS41 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006623Biological processprotein targeting to vacuole
GO_0016236Biological processmacroautophagy
GO_0009267Biological processcellular response to starvation
GO_0016192Biological processvesicle-mediated transport
GO_0008333Biological processendosome to lysosome transport
GO_1902774Biological processlate endosome to lysosome transport
GO_0035542Biological processregulation of SNARE complex assembly
GO_0034058Biological processendosomal vesicle fusion
GO_0031902Cellular componentlate endosome membrane
GO_0030897Cellular componentHOPS complex
GO_1902501Cellular componentlysosomal HOPS complex
GO_0031901Cellular componentearly endosome membrane
GO_0005764Cellular componentlysosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0071439Cellular componentclathrin complex
GO_0005794Cellular componentGolgi apparatus
GO_0030123Cellular componentAP-3 adaptor complex
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005770Cellular componentlate endosome
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0042802Molecular functionidentical protein binding
GO_0008017Molecular functionmicrotubule binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVPS41
Protein nameVacuolar protein sorting-associated protein 41 homolog (S53)
VPS41 subunit of HOPS complex
Uncharacterized protein VPS41
Vacuolar protein sorting-associated protein 41 homolog
Synonyms
DescriptionFUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes . Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo . Required for fusion of autophagosomes with lysosomes . Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion . Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS . Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway . .

FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. .

AccessionsENST00000448833.5
H7BZX6
H7BXH3
ENST00000439468.1
Q75MX9
P49754
ENST00000457055.1
C9J2U9
ENST00000395969.6 [P49754-3]
ENST00000413141.5
C9J3F8
H7C0K2
ENST00000414632.5
ENST00000418457.6
Q75MS1
Q75MS2
ENST00000265745.13
ENST00000310301.9 [P49754-1]
C9JU58
C9JZ11