Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| microglial cell | 9 studies | 36% ± 12% | |
| endothelial cell | 8 studies | 25% ± 9% | |
| retinal cone cell | 5 studies | 24% ± 9% | |
| myeloid cell | 4 studies | 23% ± 6% | |
| dendritic cell | 4 studies | 21% ± 3% | |
| retinal rod cell | 3 studies | 33% ± 1% | |
| glutamatergic neuron | 3 studies | 32% ± 13% | |
| oligodendrocyte precursor cell | 3 studies | 28% ± 4% | |
| neuron | 3 studies | 22% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 26% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 2581.26 | 2640 / 2642 | 100% | 31.46 | 705 / 705 |
| breast | 99% | 1237.08 | 454 / 459 | 90% | 8.98 | 1002 / 1118 |
| adrenal gland | 100% | 2769.67 | 258 / 258 | 83% | 8.79 | 192 / 230 |
| lung | 100% | 2370.49 | 578 / 578 | 83% | 6.70 | 964 / 1155 |
| kidney | 97% | 955.90 | 86 / 89 | 86% | 13.53 | 777 / 901 |
| ovary | 100% | 2053.38 | 180 / 180 | 81% | 7.04 | 349 / 430 |
| thymus | 98% | 1025.70 | 642 / 653 | 83% | 6.70 | 501 / 605 |
| intestine | 99% | 1128.65 | 959 / 966 | 72% | 5.01 | 381 / 527 |
| esophagus | 93% | 924.24 | 1339 / 1445 | 78% | 5.55 | 143 / 183 |
| uterus | 100% | 1868.17 | 170 / 170 | 62% | 4.74 | 285 / 459 |
| bladder | 100% | 1279.00 | 21 / 21 | 61% | 4.04 | 307 / 504 |
| stomach | 78% | 518.49 | 280 / 359 | 81% | 6.89 | 231 / 286 |
| skin | 70% | 426.20 | 1267 / 1809 | 87% | 11.30 | 410 / 472 |
| pancreas | 60% | 358.10 | 197 / 328 | 91% | 9.36 | 162 / 178 |
| prostate | 98% | 1036.12 | 239 / 245 | 45% | 2.28 | 224 / 502 |
| spleen | 100% | 2610.71 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2236.31 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 1458.02 | 1199 / 1204 | 0% | 0 | 0 / 0 |
| heart | 100% | 2724.73 | 857 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 6.30 | 25 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 71% | 6.01 | 32 / 45 |
| liver | 35% | 202.07 | 78 / 226 | 33% | 1.90 | 136 / 406 |
| eye | 0% | 0 | 0 / 0 | 38% | 2.39 | 30 / 80 |
| peripheral blood | 36% | 230.58 | 334 / 929 | 0% | 0 | 0 / 0 |
| muscle | 31% | 137.11 | 248 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0001525 | Biological process | angiogenesis |
| GO_2000772 | Biological process | regulation of cellular senescence |
| GO_0043537 | Biological process | negative regulation of blood vessel endothelial cell migration |
| GO_0045765 | Biological process | regulation of angiogenesis |
| GO_1901491 | Biological process | negative regulation of lymphangiogenesis |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0001937 | Biological process | negative regulation of endothelial cell proliferation |
| GO_0060716 | Biological process | labyrinthine layer blood vessel development |
| GO_0006508 | Biological process | proteolysis |
| GO_0009611 | Biological process | response to wounding |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0045177 | Cellular component | apical part of cell |
| GO_0106423 | Molecular function | tubulin-tyrosine carboxypeptidase |
| GO_0004181 | Molecular function | metallocarboxypeptidase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003779 | Molecular function | actin binding |
| Gene name | VASH1 |
| Protein name | Tubulinyl-Tyr carboxypeptidase 1 (EC 3.4.17.17) (Tubulin carboxypeptidase 1) (Tyrosine carboxypeptidase 1) (TTCP 1) (Vasohibin-1) Vasohibin 1 |
| Synonyms | VASH KIAA1036 |
| Description | FUNCTION: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function . Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning . Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis . This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts . . |
| Accessions | ENST00000554237.1 [Q7L8A9-2] ENST00000554743.1 G3V4N9 Q7L8A9 ENST00000167106.9 [Q7L8A9-1] |
