USP4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	12 studies	26% ± 10%	Explore
classical monocyte	11 studies	23% ± 7%	Explore
microglial cell	10 studies	30% ± 8%	Explore
endothelial cell	9 studies	26% ± 8%	Explore
myeloid cell	8 studies	29% ± 5%	Explore
dendritic cell	8 studies	24% ± 10%	Explore
natural killer cell	7 studies	16% ± 1%	Explore
monocyte	7 studies	27% ± 9%	Explore
epithelial cell	6 studies	26% ± 9%	Explore
non-classical monocyte	5 studies	23% ± 6%	Explore
glutamatergic neuron	5 studies	43% ± 19%	Explore
B cell	5 studies	18% ± 3%	Explore
ciliated cell	5 studies	19% ± 3%	Explore
regulatory T cell	5 studies	18% ± 2%	Explore
astrocyte	5 studies	30% ± 9%	Explore
conventional dendritic cell	4 studies	30% ± 9%	Explore
neuron	4 studies	24% ± 9%	Explore
oligodendrocyte precursor cell	4 studies	23% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	19% ± 2%	Explore
adipocyte	4 studies	18% ± 3%	Explore
lymphocyte	4 studies	21% ± 4%	Explore
CD8-positive, alpha-beta T cell	4 studies	17% ± 2%	Explore
GABAergic neuron	4 studies	40% ± 14%	Explore
oligodendrocyte	4 studies	19% ± 1%	Explore
plasmacytoid dendritic cell	4 studies	20% ± 3%	Explore
gamma-delta T cell	4 studies	20% ± 5%	Explore
hematopoietic precursor cell	3 studies	20% ± 3%	Explore
mucosal invariant T cell	3 studies	17% ± 1%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	17% ± 1%	Explore
mononuclear phagocyte	3 studies	22% ± 5%	Explore
abnormal cell	3 studies	18% ± 2%	Explore
alveolar macrophage	3 studies	26% ± 7%	Explore
endothelial cell of lymphatic vessel	3 studies	19% ± 2%	Explore
type I pneumocyte	3 studies	18% ± 3%	Explore
goblet cell	3 studies	29% ± 17%	Explore
T cell	3 studies	17% ± 2%	Explore
interneuron	3 studies	37% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	19% ± 4%	Explore
brain	7 studies	32% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4012.93	1445 / 1445	100%	22.05	183 / 183
intestine	100%	3857.82	966 / 966	100%	25.74	527 / 527
lung	100%	4982.04	578 / 578	100%	26.51	1155 / 1155
ovary	100%	3747.47	180 / 180	100%	32.18	430 / 430
prostate	100%	4170.43	245 / 245	100%	27.41	502 / 502
skin	100%	4653.61	1809 / 1809	100%	36.44	472 / 472
stomach	100%	2602.04	359 / 359	100%	24.33	286 / 286
thymus	100%	4163.06	653 / 653	100%	37.45	605 / 605
uterus	100%	4385.85	170 / 170	100%	29.79	459 / 459
brain	100%	3325.04	2638 / 2642	100%	34.60	705 / 705
breast	100%	4204.43	459 / 459	100%	35.70	1115 / 1118
kidney	100%	3129.30	89 / 89	100%	24.21	898 / 901
bladder	100%	4237.57	21 / 21	100%	27.07	502 / 504
pancreas	99%	1740.67	325 / 328	99%	28.14	177 / 178
adrenal gland	100%	3114.59	258 / 258	98%	16.74	225 / 230
liver	100%	1734.81	226 / 226	95%	13.05	387 / 406
adipose	100%	4170.94	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4137.37	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	20.43	80 / 80
lymph node	0%	0	0 / 0	100%	33.73	29 / 29
muscle	100%	2425.68	803 / 803	0%	0	0 / 0
spleen	100%	5555.46	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	29.55	45 / 45
ureter	0%	0	0 / 0	100%	14.13	1 / 1
peripheral blood	100%	6456.58	928 / 929	0%	0	0 / 0
heart	99%	2767.07	851 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016579	Biological process	protein deubiquitination
GO_0031397	Biological process	negative regulation of protein ubiquitination
GO_1904263	Biological process	positive regulation of TORC1 signaling
GO_0000244	Biological process	spliceosomal tri-snRNP complex assembly
GO_0006508	Biological process	proteolysis
GO_0034394	Biological process	protein localization to cell surface
GO_0031647	Biological process	regulation of protein stability
GO_0005764	Cellular component	lysosome
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0031685	Molecular function	adenosine receptor binding
GO_0005515	Molecular function	protein binding
GO_0042802	Molecular function	identical protein binding
GO_0046872	Molecular function	metal ion binding
GO_0004843	Molecular function	cysteine-type deubiquitinase activity

IV. Literature review

[source]

Gene name	USP4
Protein name	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog) Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Alternative protein USP4 ubiquitinyl hydrolase 1 (EC 3.4.19.12)
Synonyms	UNPH UNP
Description	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins . Deubiquitinates PDPK1 . Deubiquitinates TRIM21 . Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface . Deubiquitinates HAS2 . Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling . May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 . This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP . May also play a role in the regulation of quality control in the ER . . FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. . FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .
Accessions	ENST00000415188.1 ENST00000431357.1 L8EBI0 C9JNU9 ENST00000265560.9 [Q13107-1] ENST00000351842.8 [Q13107-2] Q08AK7 Q13107 ENST00000416417.5 [Q13107-3] H7C189

USP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review