USP39 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0000245Biological processspliceosomal complex assembly
GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0051301Biological processcell division
GO_0046540Cellular componentU4/U6 x U5 tri-snRNP complex
GO_0005654Cellular componentnucleoplasm
GO_0005681Cellular componentspliceosomal complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameUSP39
Protein nameUbiquitin specific peptidase 39, isoform CRA_b (cDNA FLJ31772 fis, clone NT2RI2008007, highly similar to U4/U6.U5 tri-snRNP-associated protein 2)
Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein)
Ubiquitin specific peptidase 39
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
SynonymsHSPC332
PRO2855
hCG_34614
CGI-21
DescriptionFUNCTION: Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development . Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome . Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint . Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 . Plays also an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair . Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination . Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA . .

AccessionsQ53GS9
ENST00000467885.6
ENST00000613444.4
ENST00000323701.11 [Q53GS9-1]
A0A087WW31
ENST00000458268.5
ENST00000409470.5 [Q53GS9-1]
B9A018
ENST00000409025.5
A0A087X1B2
B3KPG7
ENST00000450066.6 [Q53GS9-2]
C9J0X5
F8WC91
C9JIU2
ENST00000448971.5
ENST00000442708.5
ENST00000409766.7 [Q53GS9-3]