USP25 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071108Biological processprotein K48-linked deubiquitination
GO_1902883Biological processnegative regulation of response to oxidative stress
GO_1903882Biological processnegative regulation of interleukin-17-mediated signaling pathway
GO_0031647Biological processregulation of protein stability
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0036211Biological processprotein modification process
GO_0006508Biological processproteolysis
GO_1904293Biological processnegative regulation of ERAD pathway
GO_0016579Biological processprotein deubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008233Molecular functionpeptidase activity
GO_0101005Molecular functiondeubiquitinase activity
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0019783Molecular functionubiquitin-like protein peptidase activity
GO_0032183Molecular functionSUMO binding
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameUSP25
Protein nameUbiquitin specific peptidase 25
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
SynonymsUSP21
DescriptionFUNCTION: Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation, immune response . Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2 . Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program . Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2 . In turn, restricts virus production by regulating cholesterol biosynthetic flux . Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6 . Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance . .; FUNCTION: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.

AccessionsQ9UHP3
ENST00000285679.10 [Q9UHP3-2]
ENST00000449491.1
Q96B65
ENST00000285681.6 [Q9UHP3-1]
H7C1T8
ENST00000351097.9
ENST00000453553.1
H7C253
ENST00000400183.7 [Q9UHP3-3]