Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 21 studies | 27% ± 11% | |
fibroblast | 8 studies | 20% ± 3% | |
B cell | 7 studies | 24% ± 6% | |
dendritic cell | 7 studies | 28% ± 10% | |
macrophage | 7 studies | 24% ± 7% | |
smooth muscle cell | 7 studies | 20% ± 2% | |
oligodendrocyte | 7 studies | 25% ± 8% | |
naive B cell | 6 studies | 21% ± 4% | |
microglial cell | 6 studies | 22% ± 5% | |
endothelial cell of vascular tree | 6 studies | 25% ± 11% | |
pericyte | 6 studies | 25% ± 7% | |
monocyte | 5 studies | 17% ± 1% | |
epithelial cell | 5 studies | 36% ± 17% | |
endothelial cell of lymphatic vessel | 5 studies | 26% ± 4% | |
erythrocyte | 5 studies | 33% ± 18% | |
type I pneumocyte | 4 studies | 22% ± 6% | |
classical monocyte | 4 studies | 29% ± 6% | |
non-classical monocyte | 4 studies | 28% ± 8% | |
conventional dendritic cell | 4 studies | 22% ± 6% | |
myeloid cell | 4 studies | 27% ± 5% | |
retinal cone cell | 4 studies | 29% ± 6% | |
astrocyte | 4 studies | 27% ± 11% | |
type II pneumocyte | 4 studies | 21% ± 5% | |
ciliated cell | 3 studies | 21% ± 4% | |
lymphocyte | 3 studies | 20% ± 4% | |
capillary endothelial cell | 3 studies | 21% ± 6% | |
hepatocyte | 3 studies | 40% ± 31% | |
GABAergic neuron | 3 studies | 40% ± 3% | |
glutamatergic neuron | 3 studies | 52% ± 3% | |
oligodendrocyte precursor cell | 3 studies | 27% ± 8% | |
pancreatic A cell | 3 studies | 23% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4450.96 | 1444 / 1445 | 100% | 32.05 | 183 / 183 |
brain | 100% | 3090.89 | 2640 / 2642 | 100% | 25.58 | 705 / 705 |
lung | 100% | 4518.61 | 578 / 578 | 100% | 24.45 | 1154 / 1155 |
stomach | 100% | 2829.52 | 359 / 359 | 100% | 37.48 | 285 / 286 |
breast | 100% | 3007.36 | 459 / 459 | 99% | 27.68 | 1110 / 1118 |
prostate | 100% | 2817.40 | 244 / 245 | 99% | 18.40 | 499 / 502 |
intestine | 100% | 5610.93 | 966 / 966 | 99% | 36.91 | 521 / 527 |
thymus | 100% | 2778.63 | 653 / 653 | 99% | 21.54 | 597 / 605 |
bladder | 100% | 4453.57 | 21 / 21 | 99% | 22.95 | 497 / 504 |
pancreas | 99% | 1448.34 | 325 / 328 | 99% | 24.94 | 177 / 178 |
uterus | 100% | 2673.89 | 170 / 170 | 98% | 20.53 | 452 / 459 |
kidney | 100% | 2904.67 | 89 / 89 | 98% | 28.51 | 886 / 901 |
skin | 100% | 3299.89 | 1808 / 1809 | 96% | 25.56 | 452 / 472 |
ovary | 100% | 2662.45 | 180 / 180 | 95% | 13.12 | 409 / 430 |
liver | 100% | 2208.81 | 226 / 226 | 94% | 14.40 | 380 / 406 |
adrenal gland | 100% | 1655.30 | 257 / 258 | 93% | 28.79 | 214 / 230 |
blood vessel | 100% | 4115.02 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 34.10 | 29 / 29 |
spleen | 100% | 2616.72 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 20.22 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.94 | 1 / 1 |
adipose | 100% | 3517.95 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 99% | 1409.53 | 791 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 1741.88 | 831 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 86% | 12.85 | 69 / 80 |
peripheral blood | 66% | 2144.66 | 615 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016579 | Biological process | protein deubiquitination |
GO_0006508 | Biological process | proteolysis |
GO_0005575 | Cellular component | cellular_component |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0004197 | Molecular function | cysteine-type endopeptidase activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
Gene name | USP12 |
Protein name | Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.4.19.12) (Deubiquitinating enzyme 12) (Ubiquitin thioesterase 12) (Ubiquitin-hydrolyzing enzyme 1) (Ubiquitin-specific-processing protease 12) ubiquitinyl hydrolase 1 (EC 3.4.19.12) Ubiquitin specific peptidase 12 |
Synonyms | USP12L1 UBH1 |
Description | FUNCTION: Deubiquitinating enzyme that plays various roles in the regulation of the immune response and inflammation . In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability . During TCR engagement and activation, translocates into the cytoplasm and deubiquitinates its substrates LAT and TRAT1 and prevents their lysosome-dependent degradation to stabilize the TCR signaling complex at the plasma membrane . Plays an essential role in the selective LPS-induced macrophage response through the activation of NF-kappa-B pathway . In addition, promotes that antiviral immune response through targeting DNA sensor IFI16 to inhibit its proteasome-dependent degradation . Participates in the interferon signaling pathway and antiviral response independently of its deubiquitinase activity by maintaining nuclear phosphorylated STAT1 levels via inhibition of its CREBBP-mediated acetylation and subsequent dephosphorylation . Plays an intrinsic role in promoting the differentiation, activation and proliferation of CD4(+) T-cell by activating the NF-kappa-B signaling pathway through deubiquitinating and stabilizing B-cell lymphoma/leukemia 10/BCL10 (By similarity). In myeloid-derived suppressor cells promotes the activation of the NF-kappa-B via deubiquitination and stabilization of RELA (By similarity). Regulates the 'Lys-63'-linked polyubiquitin chains of BAX and thereby modulates the mitochondrial apoptotic process . .; FUNCTION: (Microbial infection) Forms a complex with Epstein-Barr virus protein EBNA3 which is an active deubiquitinase activity that may select specific substrates to promote B-lymphocyte transformation. . |
Accessions | A0A087WWP2 O75317 ENST00000612674.1 ENST00000282344.11 ENST00000620323.1 A0A087WUU2 |