USP12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016579Biological processprotein deubiquitination
GO_0006508Biological processproteolysis
GO_0005575Cellular componentcellular_component
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameUSP12
Protein nameUbiquitin carboxyl-terminal hydrolase 12 (EC 3.4.19.12) (Deubiquitinating enzyme 12) (Ubiquitin thioesterase 12) (Ubiquitin-hydrolyzing enzyme 1) (Ubiquitin-specific-processing protease 12)
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
Ubiquitin specific peptidase 12
SynonymsUSP12L1
UBH1
DescriptionFUNCTION: Deubiquitinating enzyme that plays various roles in the regulation of the immune response and inflammation . In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability . During TCR engagement and activation, translocates into the cytoplasm and deubiquitinates its substrates LAT and TRAT1 and prevents their lysosome-dependent degradation to stabilize the TCR signaling complex at the plasma membrane . Plays an essential role in the selective LPS-induced macrophage response through the activation of NF-kappa-B pathway . In addition, promotes that antiviral immune response through targeting DNA sensor IFI16 to inhibit its proteasome-dependent degradation . Participates in the interferon signaling pathway and antiviral response independently of its deubiquitinase activity by maintaining nuclear phosphorylated STAT1 levels via inhibition of its CREBBP-mediated acetylation and subsequent dephosphorylation . Plays an intrinsic role in promoting the differentiation, activation and proliferation of CD4(+) T-cell by activating the NF-kappa-B signaling pathway through deubiquitinating and stabilizing B-cell lymphoma/leukemia 10/BCL10 (By similarity). In myeloid-derived suppressor cells promotes the activation of the NF-kappa-B via deubiquitination and stabilization of RELA (By similarity). Regulates the 'Lys-63'-linked polyubiquitin chains of BAX and thereby modulates the mitochondrial apoptotic process . .; FUNCTION: (Microbial infection) Forms a complex with Epstein-Barr virus protein EBNA3 which is an active deubiquitinase activity that may select specific substrates to promote B-lymphocyte transformation. .

AccessionsA0A087WWP2
O75317
ENST00000612674.1
ENST00000282344.11
ENST00000620323.1
A0A087WUU2