Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 20 studies | 23% ± 8% | |
plasmacytoid dendritic cell | 15 studies | 44% ± 12% | |
ciliated cell | 15 studies | 37% ± 14% | |
non-classical monocyte | 13 studies | 32% ± 18% | |
classical monocyte | 9 studies | 27% ± 16% | |
monocyte | 7 studies | 24% ± 9% | |
microglial cell | 7 studies | 25% ± 6% | |
conventional dendritic cell | 6 studies | 32% ± 20% | |
epithelial cell | 6 studies | 26% ± 10% | |
B cell | 5 studies | 22% ± 4% | |
dendritic cell | 5 studies | 37% ± 20% | |
alveolar macrophage | 4 studies | 21% ± 8% | |
myeloid cell | 4 studies | 29% ± 13% | |
type I pneumocyte | 4 studies | 23% ± 5% | |
respiratory goblet cell | 3 studies | 30% ± 14% | |
plasma cell | 3 studies | 25% ± 8% | |
tissue-resident macrophage | 3 studies | 20% ± 3% | |
basal cell | 3 studies | 33% ± 11% | |
mononuclear phagocyte | 3 studies | 30% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 100% | 2181.54 | 964 / 966 | 99% | 69.69 | 524 / 527 |
lung | 100% | 3620.03 | 578 / 578 | 99% | 61.66 | 1144 / 1155 |
esophagus | 99% | 1388.50 | 1437 / 1445 | 99% | 66.54 | 182 / 183 |
stomach | 100% | 1540.37 | 358 / 359 | 99% | 75.06 | 283 / 286 |
breast | 100% | 1867.17 | 459 / 459 | 98% | 48.15 | 1100 / 1118 |
pancreas | 99% | 1083.78 | 326 / 328 | 99% | 90.50 | 176 / 178 |
bladder | 100% | 2242.29 | 21 / 21 | 98% | 74.16 | 495 / 504 |
prostate | 100% | 1922.58 | 245 / 245 | 98% | 30.81 | 493 / 502 |
thymus | 100% | 1803.71 | 652 / 653 | 97% | 39.86 | 588 / 605 |
skin | 100% | 1605.35 | 1808 / 1809 | 97% | 36.02 | 458 / 472 |
uterus | 98% | 959.78 | 167 / 170 | 98% | 55.13 | 448 / 459 |
kidney | 100% | 1723.56 | 89 / 89 | 93% | 34.98 | 841 / 901 |
ovary | 92% | 664.56 | 166 / 180 | 100% | 103.45 | 430 / 430 |
liver | 100% | 904.00 | 225 / 226 | 88% | 24.15 | 357 / 406 |
brain | 71% | 499.95 | 1884 / 2642 | 73% | 22.77 | 517 / 705 |
adrenal gland | 100% | 1898.21 | 258 / 258 | 34% | 6.12 | 78 / 230 |
adipose | 100% | 2057.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 46.63 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 101.16 | 29 / 29 |
peripheral blood | 100% | 5483.65 | 929 / 929 | 0% | 0 | 0 / 0 |
spleen | 100% | 8602.59 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 45.27 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 108.03 | 1 / 1 |
blood vessel | 99% | 1313.71 | 1323 / 1335 | 0% | 0 | 0 / 0 |
heart | 72% | 451.98 | 621 / 861 | 0% | 0 | 0 / 0 |
muscle | 16% | 78.88 | 132 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0002224 | Biological process | toll-like receptor signaling pathway |
GO_0032755 | Biological process | positive regulation of interleukin-6 production |
GO_0034154 | Biological process | toll-like receptor 7 signaling pathway |
GO_0045087 | Biological process | innate immune response |
GO_0034138 | Biological process | toll-like receptor 3 signaling pathway |
GO_0051607 | Biological process | defense response to virus |
GO_0032735 | Biological process | positive regulation of interleukin-12 production |
GO_0006886 | Biological process | intracellular protein transport |
GO_0002457 | Biological process | T cell antigen processing and presentation |
GO_0019886 | Biological process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
GO_0000902 | Biological process | cell morphogenesis |
GO_0034162 | Biological process | toll-like receptor 9 signaling pathway |
GO_0032009 | Cellular component | early phagosome |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005764 | Cellular component | lysosome |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005768 | Cellular component | endosome |
GO_0035325 | Molecular function | Toll-like receptor binding |
GO_0005515 | Molecular function | protein binding |
Gene name | UNC93B1 |
Protein name | Unc-93 homolog B1, TLR signaling regulator Protein unc-93 homolog B1 (Unc-93B1) (hUNC93B1) UNC93B1 protein |
Synonyms | UNC93 UNC93B |
Description | FUNCTION: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. . |
Accessions | ENST00000524455.5 ENST00000528423.1 E9PR93 Q58F16 E9PNE5 Q9H1C4 ENST00000227471.7 Q05BS6 |