UNC93B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002224Biological processtoll-like receptor signaling pathway
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0034154Biological processtoll-like receptor 7 signaling pathway
GO_0045087Biological processinnate immune response
GO_0034138Biological processtoll-like receptor 3 signaling pathway
GO_0051607Biological processdefense response to virus
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0006886Biological processintracellular protein transport
GO_0002457Biological processT cell antigen processing and presentation
GO_0019886Biological processantigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0000902Biological processcell morphogenesis
GO_0034162Biological processtoll-like receptor 9 signaling pathway
GO_0032009Cellular componentearly phagosome
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005764Cellular componentlysosome
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005768Cellular componentendosome
GO_0035325Molecular functionToll-like receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUNC93B1
Protein nameUnc-93 homolog B1, TLR signaling regulator
Protein unc-93 homolog B1 (Unc-93B1) (hUNC93B1)
UNC93B1 protein
SynonymsUNC93
UNC93B
DescriptionFUNCTION: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. .

AccessionsENST00000524455.5
ENST00000528423.1
E9PR93
Q58F16
E9PNE5
Q9H1C4
ENST00000227471.7
Q05BS6