UNC13B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071333Biological processcellular response to glucose stimulus
GO_0099011Biological processneuronal dense core vesicle exocytosis
GO_0061789Biological processdense core granule priming
GO_0016081Biological processsynaptic vesicle docking
GO_0060478Biological processacrosomal vesicle exocytosis
GO_0050714Biological processpositive regulation of protein secretion
GO_0099525Biological processpresynaptic dense core vesicle exocytosis
GO_0097151Biological processpositive regulation of inhibitory postsynaptic potential
GO_0007268Biological processchemical synaptic transmission
GO_0016082Biological processsynaptic vesicle priming
GO_0010808Biological processpositive regulation of synaptic vesicle priming
GO_0043065Biological processpositive regulation of apoptotic process
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0016020Cellular componentmembrane
GO_0043195Cellular componentterminal bouton
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0005794Cellular componentGolgi apparatus
GO_0042734Cellular componentpresynaptic membrane
GO_0048786Cellular componentpresynaptic active zone
GO_0005829Cellular componentcytosol
GO_0098831Cellular componentpresynaptic active zone cytoplasmic component
GO_0005543Molecular functionphospholipid binding
GO_0030742Molecular functionGTP-dependent protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0017075Molecular functionsyntaxin-1 binding
GO_0005516Molecular functioncalmodulin binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0019992Molecular functiondiacylglycerol binding

IV. Literature review

[source]
Gene nameUNC13B
Protein nameUNC13B variant protein
Protein unc-13 homolog B (Munc13-2) (munc13)
Unc-13 homolog B
UNC13B protein (Unc-13 homolog B)
Synonymsvariant
protein
UNC13
DescriptionFUNCTION: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). .

AccessionsENST00000378495.7 [O14795-1]
A0A0U1RRL2
Q4LE73
I6L9J0
A0A1B0GVW8
ENST00000481299.1
ENST00000636694.1
ENST00000634487.1
ENST00000396787.5
A0A0U1RRB5
B1AM27
ENST00000635942.2
ENST00000617908.4
ENST00000619578.4 [O14795-2]
O14795
A0A1B0GUS7