UBXN2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000045Biological processautophagosome assembly
GO_0061025Biological processmembrane fusion
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0031396Biological processregulation of protein ubiquitination
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0007030Biological processGolgi organization
GO_0045861Biological processnegative regulation of proteolysis
GO_1904293Biological processnegative regulation of ERAD pathway
GO_0031468Biological processnuclear membrane reassembly
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005801Cellular componentcis-Golgi network
GO_0043204Cellular componentperikaryon
GO_0005794Cellular componentGolgi apparatus
GO_0030425Cellular componentdendrite
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0033130Molecular functionacetylcholine receptor binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameUBXN2A
Protein nameUBX domain-containing protein 2A (UBX domain-containing protein 4)
SynonymsUBXD4
DescriptionFUNCTION: Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons . Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation (By similarity). Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9 . Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway . .

AccessionsP68543
ENST00000309033.5 [P68543-1]
ENST00000404924.5 [P68543-1]