UBQLN2 | OmnibusX

Name	Number of supported studies	Average coverage
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	20% ± 5%	Explore
CD4-positive, alpha-beta T cell	4 studies	18% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	18% ± 5%	Explore
classical monocyte	3 studies	20% ± 3%	Explore
neuron	3 studies	29% ± 10%	Explore
epithelial cell	3 studies	30% ± 4%	Explore
fibroblast	3 studies	19% ± 2%	Explore
regulatory T cell	3 studies	20% ± 3%	Explore
GABAergic neuron	3 studies	29% ± 7%	Explore
glutamatergic neuron	3 studies	33% ± 13%	Explore

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	17% ± 1%	Explore
brain	3 studies	23% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3131.72	1445 / 1445	100%	71.18	183 / 183
uterus	100%	2898.44	170 / 170	100%	51.70	459 / 459
brain	100%	4967.14	2640 / 2642	100%	75.62	705 / 705
prostate	100%	2538.10	245 / 245	100%	56.45	501 / 502
stomach	100%	1953.27	359 / 359	100%	50.23	285 / 286
breast	100%	2532.55	459 / 459	100%	58.81	1113 / 1118
ovary	100%	2977.66	180 / 180	100%	43.90	428 / 430
intestine	100%	2860.40	966 / 966	99%	42.86	524 / 527
lung	100%	2471.13	576 / 578	100%	50.51	1152 / 1155
thymus	100%	3091.98	652 / 653	100%	76.46	602 / 605
bladder	100%	3039.62	21 / 21	99%	51.46	500 / 504
skin	100%	2991.68	1808 / 1809	99%	49.42	466 / 472
adrenal gland	100%	3275.22	258 / 258	98%	65.54	226 / 230
kidney	100%	1874.57	89 / 89	98%	41.92	883 / 901
liver	100%	1731.54	225 / 226	94%	25.23	380 / 406
pancreas	91%	958.59	299 / 328	99%	44.14	176 / 178
adipose	100%	2574.17	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3127.93	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	39.88	29 / 29
muscle	100%	3183.16	803 / 803	0%	0	0 / 0
spleen	100%	2390.72	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	52.09	45 / 45
ureter	0%	0	0 / 0	100%	16.79	1 / 1
heart	97%	2063.84	833 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	30.38	77 / 80
peripheral blood	92%	2235.73	852 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_1900186	Biological process	negative regulation of clathrin-dependent endocytosis
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_1904294	Biological process	positive regulation of ERAD pathway
GO_0016241	Biological process	regulation of macroautophagy
GO_1904021	Biological process	negative regulation of G protein-coupled receptor internalization
GO_2000785	Biological process	regulation of autophagosome assembly
GO_0036503	Biological process	ERAD pathway
GO_0000045	Biological process	autophagosome assembly
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0005776	Cellular component	autophagosome
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0031593	Molecular function	polyubiquitin modification-dependent protein binding
GO_0140693	Molecular function	molecular condensate scaffold activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

Gene name	UBQLN2
Protein name	Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Synonyms	HRIHFB2157 PLIC2 N4BP4
Description	FUNCTION: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome . Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome . Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion . Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) . .
Accessions	ENST00000338222.7 Q9UHD9

UBQLN2 report