UBLCP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006470Biological processprotein dephosphorylation
GO_0090364Biological processregulation of proteasome assembly
GO_0032780Biological processnegative regulation of ATP-dependent activity
GO_0005730Cellular componentnucleolus
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005515Molecular functionprotein binding
GO_1904855Molecular functionproteasome regulatory particle binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0046872Molecular functionmetal ion binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity

IV. Literature review

[source]
Gene nameUBLCP1
Protein nameUbiquitin-like domain-containing CTD phosphatase 1 (EC 3.1.3.16) (Nuclear proteasome inhibitor UBLCP1)
Synonyms
DescriptionFUNCTION: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity . Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1 . Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly . Has also been reported to stimulate the proteolytic activity of the 26S proteasome . .

AccessionsENST00000296786.8
Q8WVY7