UBE2O report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0006513Biological processprotein monoubiquitination
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameUBE2O
Protein name(E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O)
Ubiquitin conjugating enzyme E2 O
SynonymsKIAA1734
DescriptionFUNCTION: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins . Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity . Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis . Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location . Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly . .

AccessionsENST00000587127.1
ENST00000590658.1
K7ES11
ENST00000319380.12
K7EQ12
Q9C0C9