Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 8 studies | 41% ± 24% | |
GABAergic neuron | 8 studies | 37% ± 22% | |
endothelial cell | 6 studies | 30% ± 13% | |
neuron | 5 studies | 24% ± 9% | |
interneuron | 5 studies | 39% ± 21% | |
oligodendrocyte precursor cell | 5 studies | 24% ± 7% | |
cardiac muscle cell | 5 studies | 21% ± 3% | |
astrocyte | 5 studies | 24% ± 5% | |
microglial cell | 4 studies | 25% ± 3% | |
retinal ganglion cell | 4 studies | 31% ± 8% | |
amacrine cell | 3 studies | 20% ± 0% | |
GABAergic interneuron | 3 studies | 23% ± 6% | |
granule cell | 3 studies | 24% ± 1% | |
plasma cell | 3 studies | 20% ± 5% | |
epithelial cell | 3 studies | 22% ± 5% | |
erythrocyte | 3 studies | 34% ± 23% | |
oligodendrocyte | 3 studies | 21% ± 0% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 10 studies | 31% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2491.42 | 1445 / 1445 | 100% | 34.03 | 183 / 183 |
ovary | 100% | 3545.58 | 180 / 180 | 100% | 23.75 | 430 / 430 |
prostate | 100% | 2999.64 | 245 / 245 | 100% | 28.53 | 502 / 502 |
skin | 100% | 3412.35 | 1808 / 1809 | 100% | 39.43 | 472 / 472 |
uterus | 100% | 3096.11 | 170 / 170 | 100% | 29.64 | 458 / 459 |
thymus | 100% | 4280.83 | 653 / 653 | 100% | 26.05 | 603 / 605 |
breast | 100% | 2491.25 | 459 / 459 | 100% | 32.85 | 1113 / 1118 |
intestine | 100% | 2469.68 | 966 / 966 | 99% | 24.86 | 524 / 527 |
bladder | 100% | 2653.43 | 21 / 21 | 99% | 28.68 | 501 / 504 |
brain | 99% | 4264.10 | 2623 / 2642 | 100% | 39.78 | 705 / 705 |
lung | 100% | 2231.17 | 576 / 578 | 100% | 29.61 | 1150 / 1155 |
stomach | 100% | 2069.63 | 358 / 359 | 99% | 24.25 | 284 / 286 |
pancreas | 100% | 2222.31 | 328 / 328 | 99% | 20.85 | 176 / 178 |
kidney | 100% | 1825.03 | 89 / 89 | 97% | 15.33 | 873 / 901 |
adrenal gland | 100% | 2172.90 | 258 / 258 | 96% | 23.39 | 221 / 230 |
liver | 100% | 1340.32 | 226 / 226 | 96% | 13.26 | 390 / 406 |
adipose | 100% | 2205.38 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 29.07 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 28.10 | 29 / 29 |
muscle | 100% | 3814.39 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3297.15 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 24.83 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.57 | 1 / 1 |
blood vessel | 100% | 2111.36 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 3220.27 | 851 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 94% | 2231.24 | 872 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0042147 | Biological process | retrograde transport, endosome to Golgi |
GO_0006513 | Biological process | protein monoubiquitination |
GO_0030513 | Biological process | positive regulation of BMP signaling pathway |
GO_0070534 | Biological process | protein K63-linked ubiquitination |
GO_0016604 | Cellular component | nuclear body |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0061631 | Molecular function | ubiquitin conjugating enzyme activity |
GO_0005515 | Molecular function | protein binding |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | UBE2O |
Protein name | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) Ubiquitin conjugating enzyme E2 O |
Synonyms | KIAA1734 |
Description | FUNCTION: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins . Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity . Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis . Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location . Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly . . |
Accessions | ENST00000587127.1 ENST00000590658.1 K7ES11 ENST00000319380.12 K7EQ12 Q9C0C9 |