UBA6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0021766Biological processhippocampus development
GO_0060996Biological processdendritic spine development
GO_0021764Biological processamygdala development
GO_0007626Biological processlocomotory behavior
GO_0007612Biological processlearning
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0019780Molecular functionFAT10 activating enzyme activity
GO_0004792Molecular functionthiosulfate sulfurtransferase activity
GO_0004839Molecular functionubiquitin activating enzyme activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameUBA6
Protein nameUbiquitin like modifier activating enzyme 6
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)
Alternative protein UBA6
SynonymsUBE1L2
MOP4
DescriptionFUNCTION: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. .

AccessionsENST00000505673.2
H0Y8S8
A0AVT1
ENST00000322244.10 [A0AVT1-1]
L8E8V3
ENST00000420827.2 [A0AVT1-3]
H0Y9U5
ENST00000514261.1