Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 16 studies | 29% ± 12% | |
oligodendrocyte | 11 studies | 31% ± 12% | |
astrocyte | 10 studies | 30% ± 14% | |
macrophage | 10 studies | 29% ± 10% | |
oligodendrocyte precursor cell | 9 studies | 30% ± 14% | |
epithelial cell | 9 studies | 32% ± 19% | |
basal cell | 8 studies | 31% ± 19% | |
glutamatergic neuron | 7 studies | 46% ± 26% | |
microglial cell | 7 studies | 28% ± 8% | |
fibroblast | 7 studies | 21% ± 7% | |
GABAergic neuron | 7 studies | 43% ± 20% | |
B cell | 6 studies | 22% ± 3% | |
endothelial cell of lymphatic vessel | 6 studies | 25% ± 7% | |
interneuron | 6 studies | 41% ± 22% | |
natural killer cell | 5 studies | 19% ± 2% | |
neuron | 5 studies | 34% ± 11% | |
myeloid cell | 5 studies | 22% ± 4% | |
ciliated cell | 5 studies | 27% ± 9% | |
club cell | 5 studies | 20% ± 5% | |
dendritic cell | 5 studies | 26% ± 11% | |
monocyte | 5 studies | 22% ± 4% | |
type I pneumocyte | 5 studies | 19% ± 5% | |
pericyte | 5 studies | 20% ± 5% | |
adipocyte | 4 studies | 19% ± 3% | |
goblet cell | 4 studies | 34% ± 26% | |
classical monocyte | 3 studies | 22% ± 5% | |
hematopoietic precursor cell | 3 studies | 27% ± 8% | |
GABAergic interneuron | 3 studies | 25% ± 9% | |
mast cell | 3 studies | 23% ± 6% | |
squamous epithelial cell | 3 studies | 36% ± 23% | |
lymphocyte | 3 studies | 27% ± 5% | |
secretory cell | 3 studies | 29% ± 10% | |
naive B cell | 3 studies | 19% ± 4% | |
leukocyte | 3 studies | 20% ± 3% | |
respiratory goblet cell | 3 studies | 24% ± 7% | |
T cell | 3 studies | 17% ± 1% | |
alveolar macrophage | 3 studies | 28% ± 7% | |
smooth muscle cell | 3 studies | 18% ± 2% | |
plasmacytoid dendritic cell | 3 studies | 25% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2893.53 | 1445 / 1445 | 100% | 28.93 | 183 / 183 |
uterus | 100% | 2983.56 | 170 / 170 | 100% | 23.88 | 459 / 459 |
lung | 100% | 3578.90 | 577 / 578 | 100% | 19.22 | 1154 / 1155 |
breast | 100% | 3029.27 | 459 / 459 | 100% | 19.25 | 1115 / 1118 |
bladder | 100% | 2705.10 | 21 / 21 | 100% | 19.73 | 502 / 504 |
prostate | 100% | 3050.09 | 245 / 245 | 100% | 13.52 | 500 / 502 |
brain | 100% | 2166.47 | 2631 / 2642 | 100% | 14.00 | 705 / 705 |
pancreas | 100% | 1309.76 | 328 / 328 | 99% | 14.39 | 176 / 178 |
kidney | 100% | 1837.07 | 89 / 89 | 99% | 11.87 | 890 / 901 |
thymus | 100% | 2532.35 | 652 / 653 | 99% | 10.42 | 597 / 605 |
stomach | 100% | 1778.35 | 359 / 359 | 98% | 14.54 | 280 / 286 |
intestine | 100% | 2496.86 | 966 / 966 | 98% | 14.72 | 515 / 527 |
adrenal gland | 100% | 2516.60 | 258 / 258 | 97% | 10.89 | 224 / 230 |
ovary | 100% | 2851.04 | 180 / 180 | 97% | 8.47 | 416 / 430 |
skin | 100% | 3108.67 | 1809 / 1809 | 92% | 12.88 | 434 / 472 |
liver | 100% | 1725.27 | 226 / 226 | 84% | 6.18 | 340 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 13.64 | 29 / 29 |
spleen | 100% | 3321.49 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 26.06 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.10 | 1 / 1 |
adipose | 100% | 2626.20 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2578.19 | 1333 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 1293.70 | 797 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 1266.59 | 837 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 85% | 2249.74 | 789 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 59% | 4.22 | 47 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0021766 | Biological process | hippocampus development |
GO_0060996 | Biological process | dendritic spine development |
GO_0021764 | Biological process | amygdala development |
GO_0007626 | Biological process | locomotory behavior |
GO_0007612 | Biological process | learning |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0016779 | Molecular function | nucleotidyltransferase activity |
GO_0019780 | Molecular function | FAT10 activating enzyme activity |
GO_0004792 | Molecular function | thiosulfate sulfurtransferase activity |
GO_0004839 | Molecular function | ubiquitin activating enzyme activity |
GO_0005515 | Molecular function | protein binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | UBA6 |
Protein name | Ubiquitin like modifier activating enzyme 6 Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) Alternative protein UBA6 |
Synonyms | UBE1L2 MOP4 |
Description | FUNCTION: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. . |
Accessions | ENST00000505673.2 H0Y8S8 A0AVT1 ENST00000322244.10 [A0AVT1-1] L8E8V3 ENST00000420827.2 [A0AVT1-3] H0Y9U5 ENST00000514261.1 |