UACA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0008150Biological processbiological_process
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0070062Cellular componentextracellular exosome
GO_0005856Cellular componentcytoskeleton
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameUACA
Protein nameUACA protein
Uveal autoantigen with coiled-coil domains and ankyrin repeats
SynonymsKIAA1561
DescriptionFUNCTION: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). .; FUNCTION: Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity). .

AccessionsENST00000322954.11 [Q9BZF9-1]
ENST00000379983.6 [Q9BZF9-2]
H0YMI1
B7ZKM7
ENST00000560167.1
ENST00000558758.5
Q05DB3
F5H2B9
H0YN48
ENST00000560441.5
Q9BZF9
H0YNH8
B7ZKM6
ENST00000539319.5