TRRAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006281Biological processDNA repair
GO_2000779Biological processregulation of double-strand break repair
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006282Biological processregulation of DNA repair
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0043484Biological processregulation of RNA splicing
GO_0051726Biological processregulation of cell cycle
GO_0000812Cellular componentSwr1 complex
GO_0000786Cellular componentnucleosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0033276Cellular componenttranscription factor TFTC complex
GO_0000124Cellular componentSAGA complex
GO_0005634Cellular componentnucleus
GO_0003712Molecular functiontranscription coregulator activity
GO_0016301Molecular functionkinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRRAP
Protein nameTransformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog)
Transformation/transcription domain associated protein
TRRAP protein
SynonymsPAF400
DescriptionFUNCTION: Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). .

AccessionsA0A994J7J3
A0A2R8YFJ4
A0A994J4S5
ENST00000446306.8
ENST00000704589.1
H0Y4W2
ENST00000704590.1
A0A994J759
ENST00000704588.1
ENST00000704587.1
ENST00000360902.2
ENST00000456197.2
A0A994J575
ENST00000359863.8 [Q9Y4A5-1]
Q9Y4A5
Q8N563
ENST00000417523.5
A0A994J4K1
ENST00000355540.7 [Q9Y4A5-2]
C9K0N1
ENST00000704591.1
F2Z2U4