Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 33% ± 18% | |
astrocyte | 10 studies | 29% ± 16% | |
oligodendrocyte precursor cell | 8 studies | 27% ± 13% | |
glutamatergic neuron | 7 studies | 34% ± 23% | |
microglial cell | 7 studies | 25% ± 10% | |
fibroblast | 7 studies | 26% ± 11% | |
oligodendrocyte | 7 studies | 29% ± 12% | |
interneuron | 6 studies | 41% ± 22% | |
epithelial cell | 6 studies | 29% ± 14% | |
GABAergic neuron | 6 studies | 36% ± 18% | |
macrophage | 5 studies | 30% ± 8% | |
adipocyte | 5 studies | 26% ± 4% | |
endothelial cell of lymphatic vessel | 5 studies | 27% ± 7% | |
granule cell | 4 studies | 23% ± 3% | |
ciliated cell | 4 studies | 23% ± 8% | |
club cell | 4 studies | 24% ± 8% | |
smooth muscle cell | 4 studies | 23% ± 3% | |
GABAergic interneuron | 3 studies | 25% ± 6% | |
neuron | 3 studies | 37% ± 19% | |
cardiac muscle cell | 3 studies | 21% ± 0% | |
basal cell | 3 studies | 35% ± 17% | |
myeloid cell | 3 studies | 23% ± 5% | |
abnormal cell | 3 studies | 28% ± 11% | |
pericyte | 3 studies | 28% ± 8% | |
type I pneumocyte | 3 studies | 26% ± 5% | |
type II pneumocyte | 3 studies | 22% ± 4% | |
lymphocyte | 3 studies | 29% ± 6% | |
goblet cell | 3 studies | 37% ± 26% | |
transit amplifying cell | 3 studies | 31% ± 23% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3894.45 | 1445 / 1445 | 100% | 28.17 | 183 / 183 |
skin | 100% | 6673.59 | 1808 / 1809 | 100% | 19.58 | 471 / 472 |
breast | 100% | 4104.08 | 459 / 459 | 100% | 18.74 | 1114 / 1118 |
intestine | 100% | 4623.13 | 966 / 966 | 99% | 17.59 | 524 / 527 |
prostate | 100% | 4561.33 | 245 / 245 | 99% | 16.03 | 499 / 502 |
thymus | 100% | 5821.33 | 653 / 653 | 99% | 17.53 | 601 / 605 |
stomach | 100% | 3414.72 | 359 / 359 | 99% | 20.63 | 284 / 286 |
bladder | 100% | 4370.19 | 21 / 21 | 99% | 13.93 | 499 / 504 |
ovary | 100% | 6243.84 | 180 / 180 | 99% | 14.79 | 425 / 430 |
lung | 100% | 4368.63 | 577 / 578 | 99% | 17.34 | 1140 / 1155 |
kidney | 100% | 3326.73 | 89 / 89 | 98% | 14.36 | 887 / 901 |
adrenal gland | 100% | 4721.25 | 258 / 258 | 98% | 11.21 | 226 / 230 |
uterus | 100% | 5682.64 | 170 / 170 | 98% | 13.02 | 451 / 459 |
pancreas | 100% | 2686.67 | 327 / 328 | 98% | 12.93 | 175 / 178 |
brain | 98% | 3413.69 | 2597 / 2642 | 99% | 17.72 | 701 / 705 |
liver | 100% | 2107.44 | 225 / 226 | 84% | 6.47 | 340 / 406 |
adipose | 100% | 3728.41 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 17.11 | 29 / 29 |
spleen | 100% | 5052.56 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 13.67 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.01 | 1 / 1 |
blood vessel | 100% | 4040.35 | 1333 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2643.78 | 800 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 10.79 | 79 / 80 |
heart | 97% | 2600.40 | 837 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 78% | 2958.45 | 724 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006325 | Biological process | chromatin organization |
GO_0006281 | Biological process | DNA repair |
GO_2000779 | Biological process | regulation of double-strand break repair |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0006282 | Biological process | regulation of DNA repair |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_1905168 | Biological process | positive regulation of double-strand break repair via homologous recombination |
GO_0043484 | Biological process | regulation of RNA splicing |
GO_0051726 | Biological process | regulation of cell cycle |
GO_0000812 | Cellular component | Swr1 complex |
GO_0000786 | Cellular component | nucleosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0035267 | Cellular component | NuA4 histone acetyltransferase complex |
GO_0033276 | Cellular component | transcription factor TFTC complex |
GO_0000124 | Cellular component | SAGA complex |
GO_0005634 | Cellular component | nucleus |
GO_0003712 | Molecular function | transcription coregulator activity |
GO_0016301 | Molecular function | kinase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | TRRAP |
Protein name | Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) Transformation/transcription domain associated protein TRRAP protein |
Synonyms | PAF400 |
Description | FUNCTION: Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). . |
Accessions | A0A994J7J3 A0A2R8YFJ4 A0A994J4S5 ENST00000446306.8 ENST00000704589.1 H0Y4W2 ENST00000704590.1 A0A994J759 ENST00000704588.1 ENST00000704587.1 ENST00000360902.2 ENST00000456197.2 A0A994J575 ENST00000359863.8 [Q9Y4A5-1] Q9Y4A5 Q8N563 ENST00000417523.5 A0A994J4K1 ENST00000355540.7 [Q9Y4A5-2] C9K0N1 ENST00000704591.1 F2Z2U4 |