Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 10 studies | 27% ± 8% | |
non-classical monocyte | 8 studies | 36% ± 21% | |
classical monocyte | 7 studies | 33% ± 16% | |
endothelial cell | 6 studies | 20% ± 4% | |
fibroblast | 6 studies | 30% ± 18% | |
astrocyte | 6 studies | 25% ± 9% | |
basal cell | 5 studies | 24% ± 7% | |
smooth muscle cell | 5 studies | 17% ± 1% | |
plasmacytoid dendritic cell | 5 studies | 20% ± 3% | |
myeloid cell | 4 studies | 27% ± 10% | |
type I pneumocyte | 4 studies | 22% ± 5% | |
ionocyte | 3 studies | 45% ± 5% | |
respiratory goblet cell | 3 studies | 26% ± 4% | |
secretory cell | 3 studies | 29% ± 5% | |
squamous epithelial cell | 3 studies | 51% ± 15% | |
B cell | 3 studies | 20% ± 3% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 19% ± 3% | |
conventional dendritic cell | 3 studies | 39% ± 20% | |
epithelial cell | 3 studies | 42% ± 11% | |
macrophage | 3 studies | 16% ± 1% | |
monocyte | 3 studies | 20% ± 3% | |
rod bipolar cell | 3 studies | 35% ± 9% | |
dendritic cell | 3 studies | 39% ± 31% | |
oligodendrocyte precursor cell | 3 studies | 23% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 6216.16 | 1445 / 1445 | 100% | 74.75 | 183 / 183 |
pancreas | 100% | 6131.52 | 328 / 328 | 100% | 100.60 | 178 / 178 |
thymus | 100% | 9884.89 | 653 / 653 | 100% | 126.42 | 605 / 605 |
prostate | 100% | 7934.36 | 245 / 245 | 100% | 81.36 | 501 / 502 |
uterus | 100% | 7421.95 | 170 / 170 | 100% | 71.37 | 458 / 459 |
kidney | 100% | 9279.74 | 89 / 89 | 100% | 77.21 | 899 / 901 |
ovary | 100% | 5850.02 | 180 / 180 | 100% | 119.60 | 429 / 430 |
brain | 100% | 6919.87 | 2640 / 2642 | 100% | 93.93 | 703 / 705 |
liver | 100% | 4410.36 | 226 / 226 | 100% | 58.95 | 404 / 406 |
breast | 100% | 8133.19 | 459 / 459 | 99% | 83.48 | 1111 / 1118 |
stomach | 100% | 6543.83 | 359 / 359 | 99% | 62.25 | 284 / 286 |
intestine | 100% | 6151.78 | 966 / 966 | 99% | 61.88 | 523 / 527 |
skin | 100% | 6450.98 | 1808 / 1809 | 99% | 50.24 | 468 / 472 |
lung | 100% | 9651.19 | 578 / 578 | 99% | 84.00 | 1143 / 1155 |
adrenal gland | 100% | 6196.95 | 258 / 258 | 99% | 66.25 | 227 / 230 |
bladder | 100% | 8526.57 | 21 / 21 | 99% | 75.29 | 497 / 504 |
adipose | 100% | 9914.56 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 52.72 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 50.66 | 29 / 29 |
muscle | 100% | 6265.21 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5793.44 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 63.99 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 83.92 | 1 / 1 |
blood vessel | 100% | 9050.45 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 5756.13 | 856 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 93% | 4922.07 | 868 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
GO_0045087 | Biological process | innate immune response |
GO_0007249 | Biological process | canonical NF-kappaB signal transduction |
GO_0046597 | Biological process | negative regulation of viral entry into host cell |
GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0019827 | Biological process | stem cell population maintenance |
GO_0010508 | Biological process | positive regulation of autophagy |
GO_0070534 | Biological process | protein K63-linked ubiquitination |
GO_0044790 | Biological process | suppression of viral release by host |
GO_0032897 | Biological process | negative regulation of viral transcription |
GO_1900182 | Biological process | positive regulation of protein localization to nucleus |
GO_0005829 | Cellular component | cytosol |
GO_0016605 | Cellular component | PML body |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0031435 | Molecular function | mitogen-activated protein kinase kinase kinase binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0003713 | Molecular function | transcription coactivator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | TRIM8 |
Protein name | Tripartite motif containing 8 E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8) |
Synonyms | GERP RNF27 |
Description | FUNCTION: E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response . Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 . Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B . Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus . Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction . . |
Accessions | A0A2U3TZI0 ENST00000642664.1 A0A2R8Y580 ENST00000643100.1 ENST00000645961.1 ENST00000302424.12 A0A2R8YCF6 ENST00000642304.1 ENST00000644914.1 R4GN03 ENST00000462202.3 ENST00000643721.2 Q9BZR9 ENST00000710327.1 A0A2R8Y500 A0A2R8YD00 A0A2R8Y5K0 ENST00000643376.1 A0A2R8YFP1 |