TRIM8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045087Biological processinnate immune response
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0046597Biological processnegative regulation of viral entry into host cell
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0019827Biological processstem cell population maintenance
GO_0010508Biological processpositive regulation of autophagy
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0044790Biological processsuppression of viral release by host
GO_0032897Biological processnegative regulation of viral transcription
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0031435Molecular functionmitogen-activated protein kinase kinase kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM8
Protein nameTripartite motif containing 8
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
SynonymsGERP
RNF27
DescriptionFUNCTION: E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response . Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 . Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B . Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus . Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction . .

AccessionsA0A2U3TZI0
ENST00000642664.1
A0A2R8Y580
ENST00000643100.1
ENST00000645961.1
ENST00000302424.12
A0A2R8YCF6
ENST00000642304.1
ENST00000644914.1
R4GN03
ENST00000462202.3
ENST00000643721.2
Q9BZR9
ENST00000710327.1
A0A2R8Y500
A0A2R8YD00
A0A2R8Y5K0
ENST00000643376.1
A0A2R8YFP1