TRIM62 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM62 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045087Biological processinnate immune response
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0044314Biological processprotein K27-linked ubiquitination
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_1905036Biological processpositive regulation of antifungal innate immune response
GO_0019076Biological processviral release from host cell
GO_0046596Biological processregulation of viral entry into host cell
GO_0032897Biological processnegative regulation of viral transcription
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM62
Protein nameE3 ubiquitin-protein ligase TRIM62 (EC 2.3.2.27) (Tripartite motif-containing protein 62)
Synonyms
DescriptionFUNCTION: E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways . E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 . .

AccessionsENST00000291416.10 [Q9BVG3-1]
ENST00000543586.1 [Q9BVG3-2]
Q9BVG3