TRIM26 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0044790Biological processsuppression of viral release by host
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0046597Biological processnegative regulation of viral entry into host cell
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0045087Biological processinnate immune response
GO_0005575Cellular componentcellular_component
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameTRIM26
Protein nameTripartite motif-containing protein 26 (Zinc finger protein 173)
Tripartite motif-containing protein 26 (EC 2.3.2.27) (Acid finger protein) (AFP) (RING finger protein 95) (Zinc finger protein 173)
Tripartite motif-containing protein 26
Tripartite motif-containing protein 26 (EC 2.3.2.27) (Zinc finger protein 173)
SynonymsZNF173
RNF95
DescriptionFUNCTION: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Plays also a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA . Promotes nuclear IRF3 ubiquitination and proteasomal degradation . Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling . In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation . Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein . Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation . Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity). Inhibits directly hepatitis B virus replication by mediating HBX ubiquitination and subsequent degradation . .; FUNCTION: (Microbial infection) Promotes herpes simplex virus type 2/HHV-2 infection in vaginal epithelial cells by decreasing the nuclear localization of IRF3, the primary mediator of type I interferon activation. .

AccessionsENST00000419171.1
ENST00000451189.1
ENST00000450392.5
ENST00000416596.5
ENST00000415789.1
ENST00000438384.5
ENST00000423901.5
ENST00000453442.1
ENST00000433314.5
Q5SPU2
ENST00000438064.1
Q12899
ENST00000450103.1
ENST00000447711.6
ENST00000412755.5
ENST00000444979.1
ENST00000431641.5
ENST00000440149.1
A2AE50
ENST00000396558.5
ENST00000327357.9
ENST00000427612.5
ENST00000429583.5
ENST00000425523.5
ENST00000415923.6
ENST00000436219.5
A2AE48
ENST00000445457.1
ENST00000428486.5
ENST00000434785.5
ENST00000445259.6
ENST00000437089.5
ENST00000455000.6
ENST00000419401.5
ENST00000433361.1
ENST00000446196.5
ENST00000453195.5
ENST00000449136.5
ENST00000438908.5
ENST00000433836.1
A0A0G2JIW2
ENST00000383607.6
ENST00000415966.1
ENST00000456770.5
ENST00000422802.5
ENST00000427535.5
ENST00000446540.5
ENST00000418026.1
ENST00000435387.5
ENST00000439094.6
ENST00000456093.5
ENST00000424124.2
ENST00000425831.5
ENST00000422349.5
ENST00000447942.5
ENST00000438785.5
ENST00000422881.1
ENST00000454678.7
ENST00000432326.5