TRIB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0014912Biological processnegative regulation of smooth muscle cell migration
GO_0045645Biological processpositive regulation of eosinophil differentiation
GO_0045651Biological processpositive regulation of macrophage differentiation
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0043405Biological processregulation of MAP kinase activity
GO_0048662Biological processnegative regulation of smooth muscle cell proliferation
GO_0045659Biological processnegative regulation of neutrophil differentiation
GO_0031665Biological processnegative regulation of lipopolysaccharide-mediated signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0031434Molecular functionmitogen-activated protein kinase kinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0004672Molecular functionprotein kinase activity
GO_0055106Molecular functionubiquitin-protein transferase regulator activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIB1
Protein nameTribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)
Tribbles pseudokinase 1
SynonymsC8FW
TRB1
GIG2
DescriptionFUNCTION: Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase . The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain . Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA . Binds selectively the recognition sequence of CEBPA . Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity . .

AccessionsENST00000519576.1
E5RFH4
Q96RU8
ENST00000311922.4 [Q96RU8-1]
ENST00000520847.1 [Q96RU8-2]