Name | Number of supported studies | Average coverage | |
---|---|---|---|
plasma cell | 14 studies | 37% ± 12% | |
classical monocyte | 13 studies | 24% ± 7% | |
basal cell | 13 studies | 24% ± 6% | |
macrophage | 11 studies | 21% ± 5% | |
endothelial cell | 11 studies | 27% ± 9% | |
fibroblast | 9 studies | 24% ± 12% | |
neutrophil | 9 studies | 24% ± 8% | |
non-classical monocyte | 8 studies | 20% ± 4% | |
dendritic cell | 7 studies | 28% ± 7% | |
type II pneumocyte | 7 studies | 23% ± 9% | |
conventional dendritic cell | 7 studies | 22% ± 4% | |
epithelial cell | 7 studies | 33% ± 18% | |
IgA plasma cell | 6 studies | 25% ± 8% | |
endothelial cell of vascular tree | 6 studies | 29% ± 8% | |
monocyte | 5 studies | 23% ± 6% | |
type I pneumocyte | 5 studies | 26% ± 10% | |
IgG plasma cell | 5 studies | 23% ± 4% | |
myeloid cell | 5 studies | 37% ± 6% | |
plasmablast | 5 studies | 27% ± 11% | |
pericyte | 4 studies | 17% ± 2% | |
goblet cell | 4 studies | 28% ± 15% | |
secretory cell | 4 studies | 18% ± 2% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 23% ± 4% | |
vein endothelial cell | 4 studies | 26% ± 8% | |
abnormal cell | 3 studies | 18% ± 2% | |
enterocyte | 3 studies | 17% ± 1% | |
ciliated cell | 3 studies | 30% ± 19% | |
luminal cell of prostate epithelium | 3 studies | 22% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 99% | 2808.08 | 455 / 459 | 98% | 105.42 | 1093 / 1118 |
thymus | 100% | 14748.08 | 653 / 653 | 97% | 264.30 | 586 / 605 |
lung | 100% | 6136.39 | 576 / 578 | 96% | 80.66 | 1104 / 1155 |
stomach | 95% | 4445.41 | 340 / 359 | 99% | 91.84 | 284 / 286 |
liver | 100% | 6690.09 | 226 / 226 | 92% | 60.78 | 373 / 406 |
pancreas | 93% | 1688.38 | 304 / 328 | 96% | 70.33 | 170 / 178 |
prostate | 87% | 1889.36 | 214 / 245 | 99% | 224.91 | 499 / 502 |
skin | 88% | 1895.58 | 1588 / 1809 | 99% | 123.65 | 465 / 472 |
intestine | 82% | 2724.99 | 793 / 966 | 98% | 90.42 | 517 / 527 |
esophagus | 82% | 1507.00 | 1178 / 1445 | 98% | 98.28 | 180 / 183 |
kidney | 99% | 2675.12 | 88 / 89 | 79% | 41.11 | 709 / 901 |
bladder | 76% | 1227.62 | 16 / 21 | 98% | 83.31 | 492 / 504 |
adrenal gland | 94% | 1872.10 | 243 / 258 | 67% | 35.60 | 155 / 230 |
uterus | 62% | 858.59 | 105 / 170 | 87% | 55.60 | 399 / 459 |
brain | 74% | 960.96 | 1962 / 2642 | 48% | 16.16 | 335 / 705 |
ovary | 28% | 439.29 | 51 / 180 | 91% | 58.39 | 390 / 430 |
ureter | 0% | 0 | 0 / 0 | 100% | 77.53 | 1 / 1 |
peripheral blood | 99% | 5473.89 | 916 / 929 | 0% | 0 | 0 / 0 |
adipose | 98% | 4904.24 | 1177 / 1204 | 0% | 0 | 0 / 0 |
spleen | 98% | 3740.43 | 235 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 67.37 | 42 / 45 |
muscle | 90% | 2642.80 | 724 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 83% | 39.15 | 24 / 29 |
eye | 0% | 0 | 0 / 0 | 80% | 48.47 | 64 / 80 |
heart | 77% | 1831.06 | 667 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 46% | 833.78 | 616 / 1335 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007254 | Biological process | JNK cascade |
GO_0006469 | Biological process | negative regulation of protein kinase activity |
GO_0014912 | Biological process | negative regulation of smooth muscle cell migration |
GO_0045645 | Biological process | positive regulation of eosinophil differentiation |
GO_0045651 | Biological process | positive regulation of macrophage differentiation |
GO_0032436 | Biological process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0043433 | Biological process | negative regulation of DNA-binding transcription factor activity |
GO_0043405 | Biological process | regulation of MAP kinase activity |
GO_0048662 | Biological process | negative regulation of smooth muscle cell proliferation |
GO_0045659 | Biological process | negative regulation of neutrophil differentiation |
GO_0031665 | Biological process | negative regulation of lipopolysaccharide-mediated signaling pathway |
GO_0006468 | Biological process | protein phosphorylation |
GO_0032496 | Biological process | response to lipopolysaccharide |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0004860 | Molecular function | protein kinase inhibitor activity |
GO_0031434 | Molecular function | mitogen-activated protein kinase kinase binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0004672 | Molecular function | protein kinase activity |
GO_0055106 | Molecular function | ubiquitin-protein transferase regulator activity |
GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | TRIB1 |
Protein name | Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1) Tribbles pseudokinase 1 |
Synonyms | C8FW TRB1 GIG2 |
Description | FUNCTION: Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase . The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain . Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA . Binds selectively the recognition sequence of CEBPA . Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity . . |
Accessions | ENST00000519576.1 E5RFH4 Q96RU8 ENST00000311922.4 [Q96RU8-1] ENST00000520847.1 [Q96RU8-2] |