TNP1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TNP1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNP1 at tissue level.

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0007290Biological processspermatid nucleus elongation
GO_0035092Biological processsperm DNA condensation
GO_0006337Biological processnucleosome disassembly
GO_0031507Biological processheterochromatin formation
GO_0000012Biological processsingle strand break repair
GO_0030317Biological processflagellated sperm motility
GO_0035041Biological processsperm DNA decondensation
GO_0007289Biological processspermatid nucleus differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0019953Biological processsexual reproduction
GO_0007286Biological processspermatid development
GO_0010954Biological processpositive regulation of protein processing
GO_0001673Cellular componentmale germ cell nucleus
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNP1
Protein nameSpermatid nuclear transition protein 1 (STP-1) (TP-1)
Spermatid nuclear transition protein 1
SynonymshCG_16381
DescriptionFUNCTION: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. .

AccessionsENST00000236979.2
Q4ZG82
P09430