TMTC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055074Biological processcalcium ion homeostasis
GO_0035269Biological processprotein O-linked mannosylation
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004169Molecular functiondolichyl-phosphate-mannose-protein mannosyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0000030Molecular functionmannosyltransferase activity

IV. Literature review

[source]
Gene nameTMTC2
Protein nameProtein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)
dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109)
Transmembrane O-mannosyltransferase targeting cadherins 2
SynonymshCG_1730330
DescriptionFUNCTION: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. .

AccessionsQ8N394
F8VSH2
ENST00000549919.1
ENST00000321196.8
A0A0B4J253
F8VRQ2
ENST00000548305.5
ENST00000546590.2