TMEM30A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140331Biological processaminophospholipid translocation
GO_0006855Biological processxenobiotic transmembrane transport
GO_0010976Biological processpositive regulation of neuron projection development
GO_0061092Biological processpositive regulation of phospholipid translocation
GO_0070863Biological processpositive regulation of protein exit from endoplasmic reticulum
GO_0045332Biological processphospholipid translocation
GO_0036010Biological processprotein localization to endosome
GO_0015917Biological processaminophospholipid transport
GO_0016324Cellular componentapical plasma membrane
GO_0031902Cellular componentlate endosome membrane
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031901Cellular componentearly endosome membrane
GO_0035577Cellular componentazurophil granule membrane
GO_0005794Cellular componentGolgi apparatus
GO_1990531Cellular componentphospholipid-translocating ATPase complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0030658Cellular componenttransport vesicle membrane
GO_0005198Molecular functionstructural molecule activity
GO_0005515Molecular functionprotein binding
GO_0015247Molecular functionaminophospholipid flippase activity

IV. Literature review

[source]
Gene nameTMEM30A
Protein nameCell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A)
Transmembrane protein 30A
Cell cycle control protein
SynonymsCDC50A
C6orf67
DescriptionFUNCTION: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. .

AccessionsA0A669KBF5
ENST00000674104.1
ENST00000674038.1
ENST00000475111.6 [Q9NV96-2]
Q9NV96
ENST00000673730.1
ENST00000518161.1
ENST00000370050.9 [Q9NV96-3]
ENST00000230461.11 [Q9NV96-1]
A0A669KB92
ENST00000673989.1
ENST00000674151.1 [Q9NV96-3]
A0A669KBE6
A0A669KBA0
E5RG19