TMEM108 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006898Biological processreceptor-mediated endocytosis
GO_0008090Biological processretrograde axonal transport
GO_1990416Biological processcellular response to brain-derived neurotrophic factor stimulus
GO_0097484Biological processdendrite extension
GO_0031175Biological processneuron projection development
GO_0051388Biological processpositive regulation of neurotrophin TRK receptor signaling pathway
GO_0097106Biological processpostsynaptic density organization
GO_0021542Biological processdentate gyrus development
GO_0008150Biological processbiological_process
GO_0098815Biological processmodulation of excitatory postsynaptic potential
GO_0005575Cellular componentcellular_component
GO_0036477Cellular componentsomatodendritic compartment
GO_0005769Cellular componentearly endosome
GO_0030425Cellular componentdendrite
GO_0014069Cellular componentpostsynaptic density
GO_0010008Cellular componentendosome membrane
GO_0030424Cellular componentaxon
GO_1904115Cellular componentaxon cytoplasm
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameTMEM108
Protein nameTransmembrane protein 108
Transmembrane protein 108 (Retrolinkin)
SynonymsKIAA1690
RTLN
UNQ1875/PRO4318
DescriptionFUNCTION: Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. .

AccessionsD6RGJ9
ENST00000393130.7 [Q6UXF1-1]
ENST00000321871.11 [Q6UXF1-1]
D6R911
D6RIE1
ENST00000511555.5
ENST00000510183.1
B3KT64
ENST00000512662.5
E9PB58
ENST00000508711.5
ENST00000514894.5
ENST00000512137.5
ENST00000515826.1
D6RFH6
D6R9I6
Q6UXF1