Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 16 studies | 41% ± 16% | |
oligodendrocyte precursor cell | 15 studies | 56% ± 19% | |
GABAergic neuron | 11 studies | 56% ± 24% | |
glutamatergic neuron | 11 studies | 68% ± 16% | |
fibroblast | 9 studies | 29% ± 10% | |
neuron | 6 studies | 31% ± 10% | |
interneuron | 6 studies | 67% ± 21% | |
retinal cone cell | 6 studies | 74% ± 25% | |
retinal rod cell | 6 studies | 68% ± 33% | |
type II pneumocyte | 5 studies | 21% ± 6% | |
granule cell | 4 studies | 40% ± 29% | |
smooth muscle cell | 4 studies | 19% ± 3% | |
endothelial cell | 3 studies | 46% ± 22% | |
GABAergic interneuron | 3 studies | 62% ± 6% | |
epithelial cell | 3 studies | 29% ± 11% | |
microglial cell | 3 studies | 50% ± 4% | |
pericyte | 3 studies | 33% ± 17% | |
GABAergic amacrine cell | 3 studies | 24% ± 10% | |
ependymal cell | 3 studies | 36% ± 8% | |
club cell | 3 studies | 27% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 800.55 | 2613 / 2642 | 99% | 18.32 | 699 / 705 |
thymus | 98% | 447.95 | 641 / 653 | 82% | 8.46 | 498 / 605 |
adrenal gland | 100% | 1281.46 | 257 / 258 | 80% | 8.06 | 184 / 230 |
lung | 100% | 1246.74 | 578 / 578 | 44% | 3.23 | 513 / 1155 |
esophagus | 89% | 691.24 | 1279 / 1445 | 15% | 1.08 | 28 / 183 |
uterus | 80% | 215.27 | 136 / 170 | 21% | 2.62 | 97 / 459 |
bladder | 86% | 904.05 | 18 / 21 | 15% | 1.09 | 74 / 504 |
muscle | 94% | 464.17 | 752 / 803 | 0% | 0 | 0 / 0 |
breast | 61% | 134.62 | 279 / 459 | 28% | 1.66 | 308 / 1118 |
skin | 44% | 87.15 | 790 / 1809 | 38% | 2.37 | 177 / 472 |
intestine | 69% | 172.66 | 670 / 966 | 2% | 0.07 | 11 / 527 |
heart | 67% | 342.70 | 575 / 861 | 0% | 0 | 0 / 0 |
ovary | 6% | 10.44 | 10 / 180 | 55% | 3.15 | 236 / 430 |
adipose | 58% | 132.90 | 699 / 1204 | 0% | 0 | 0 / 0 |
prostate | 34% | 109.16 | 83 / 245 | 1% | 0.02 | 5 / 502 |
blood vessel | 33% | 86.03 | 445 / 1335 | 0% | 0 | 0 / 0 |
stomach | 28% | 52.89 | 99 / 359 | 3% | 0.27 | 8 / 286 |
spleen | 19% | 28.94 | 46 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 16% | 1.66 | 7 / 45 |
eye | 0% | 0 | 0 / 0 | 10% | 0.44 | 8 / 80 |
pancreas | 0% | 0 | 0 / 328 | 7% | 0.24 | 12 / 178 |
kidney | 3% | 4.63 | 3 / 89 | 2% | 0.13 | 16 / 901 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.10 | 1 / 29 |
peripheral blood | 3% | 5.05 | 27 / 929 | 0% | 0 | 0 / 0 |
liver | 0% | 0 | 0 / 226 | 1% | 0.03 | 3 / 406 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006898 | Biological process | receptor-mediated endocytosis |
GO_0008090 | Biological process | retrograde axonal transport |
GO_1990416 | Biological process | cellular response to brain-derived neurotrophic factor stimulus |
GO_0097484 | Biological process | dendrite extension |
GO_0031175 | Biological process | neuron projection development |
GO_0051388 | Biological process | positive regulation of neurotrophin TRK receptor signaling pathway |
GO_0097106 | Biological process | postsynaptic density organization |
GO_0021542 | Biological process | dentate gyrus development |
GO_0008150 | Biological process | biological_process |
GO_0098815 | Biological process | modulation of excitatory postsynaptic potential |
GO_0005575 | Cellular component | cellular_component |
GO_0036477 | Cellular component | somatodendritic compartment |
GO_0005769 | Cellular component | early endosome |
GO_0030425 | Cellular component | dendrite |
GO_0014069 | Cellular component | postsynaptic density |
GO_0010008 | Cellular component | endosome membrane |
GO_0030424 | Cellular component | axon |
GO_1904115 | Cellular component | axon cytoplasm |
GO_0005515 | Molecular function | protein binding |
GO_0003674 | Molecular function | molecular_function |
Gene name | TMEM108 |
Protein name | Transmembrane protein 108 Transmembrane protein 108 (Retrolinkin) |
Synonyms | KIAA1690 RTLN UNQ1875/PRO4318 |
Description | FUNCTION: Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. . |
Accessions | D6RGJ9 ENST00000393130.7 [Q6UXF1-1] ENST00000321871.11 [Q6UXF1-1] D6R911 D6RIE1 ENST00000511555.5 ENST00000510183.1 B3KT64 ENST00000512662.5 E9PB58 ENST00000508711.5 ENST00000514894.5 ENST00000512137.5 ENST00000515826.1 D6RFH6 D6R9I6 Q6UXF1 |