TFEB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0001892Biological processembryonic placenta development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009267Biological processcellular response to starvation
GO_0006959Biological processhumoral immune response
GO_0002250Biological processadaptive immune response
GO_0140367Biological processantibacterial innate immune response
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0010508Biological processpositive regulation of autophagy
GO_0032418Biological processlysosome localization
GO_0034198Biological processcellular response to amino acid starvation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006914Biological processautophagy
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTFEB
Protein nameTranscription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35)
TFEB transcription factor (Transcription factor EB)
Transcription factor EB
SynonymsAlphaTFEB
BHLHE35
DescriptionFUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response . Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF . Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation . Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity . Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes . Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 . Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy . In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer . Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity . Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response . In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation . .

AccessionsENST00000445214.2 [P19484-1]
B1AKB2
ENST00000406563
Q709A5
ENST00000343317.11 [P19484-1]
B1AKB1
ENST00000420312.6 [P19484-1]
ENST00000424495.2 [P19484-1]
P19484
ENST00000678831.1 [P19484-1]
ENST00000419396.6 [P19484-1]
ENST00000403298.9 [P19484-1]
ENST00000406563.7 [P19484-2]
ENST00000416140.6 [P19484-1]
B1AKA9
ENST00000230323.8 [P19484-1]
B1AKB5
ENST00000416140
B0QYS6
Q709B0
ENST00000677531.1 [P19484-1]
A0A7I2YQR9
Q86WB1
Q709A9
A0A1B0GXL9
ENST00000445214
ENST00000419574.6 [P19484-1]
ENST00000358871.6
ENST00000419574
ENST00000419396
ENST00000394283.5
ENST00000373033.6 [P19484-1]
ENST00000343317
B0QYS7
B1AKB4
ENST00000678871.1
Q709A8
ENST00000424495