TFB1M report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000154Biological processrRNA modification
GO_0006391Biological processtranscription initiation at mitochondrial promoter
GO_0031167Biological processrRNA methylation
GO_0005759Cellular componentmitochondrial matrix
GO_0042645Cellular componentmitochondrial nucleoid
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0003677Molecular functionDNA binding
GO_0034246Molecular functionmitochondrial transcription factor activity
GO_0000179Molecular functionrRNA (adenine-N6,N6-)-dimethyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTFB1M
Protein namerRNA adenine N(6)-methyltransferase (EC 2.1.1.-)
Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (h-mtTFB) (h-mtTFB1) (hTFB1M) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1)
SynonymshCG_32337
CGI-75
DescriptionFUNCTION: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. .

FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. .

AccessionsE5KTM5
ENST00000367166.5
Q8WVM0