Name | Number of supported studies | Average coverage | |
---|---|---|---|
pericyte | 18 studies | 31% ± 14% | |
non-classical monocyte | 17 studies | 36% ± 14% | |
classical monocyte | 11 studies | 27% ± 10% | |
mast cell | 10 studies | 25% ± 8% | |
erythrocyte | 8 studies | 32% ± 16% | |
endothelial cell | 8 studies | 26% ± 11% | |
natural killer cell | 8 studies | 25% ± 10% | |
monocyte | 7 studies | 30% ± 15% | |
CD8-positive, alpha-beta T cell | 4 studies | 31% ± 10% | |
smooth muscle cell | 3 studies | 19% ± 2% | |
glutamatergic neuron | 3 studies | 33% ± 16% | |
hematopoietic precursor cell | 3 studies | 32% ± 11% |
Insufficient scRNA-seq data for expression of TESC at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
pancreas | 100% | 2605.31 | 328 / 328 | 91% | 182.50 | 162 / 178 |
thymus | 88% | 572.25 | 575 / 653 | 88% | 155.50 | 534 / 605 |
stomach | 91% | 2963.23 | 326 / 359 | 83% | 100.07 | 237 / 286 |
prostate | 79% | 490.62 | 194 / 245 | 82% | 42.77 | 412 / 502 |
adrenal gland | 100% | 2196.62 | 258 / 258 | 48% | 22.77 | 110 / 230 |
kidney | 84% | 970.29 | 75 / 89 | 51% | 36.07 | 460 / 901 |
lung | 90% | 492.19 | 521 / 578 | 44% | 76.17 | 512 / 1155 |
bladder | 81% | 1468.52 | 17 / 21 | 50% | 60.59 | 253 / 504 |
intestine | 26% | 125.97 | 253 / 966 | 86% | 104.48 | 455 / 527 |
brain | 77% | 1244.96 | 2040 / 2642 | 23% | 6.69 | 165 / 705 |
lymph node | 0% | 0 | 0 / 0 | 100% | 116.03 | 29 / 29 |
ureter | 0% | 0 | 0 / 0 | 100% | 36.62 | 1 / 1 |
peripheral blood | 98% | 3193.24 | 915 / 929 | 0% | 0 | 0 / 0 |
heart | 97% | 1578.71 | 839 / 861 | 0% | 0 | 0 / 0 |
spleen | 95% | 577.54 | 228 / 241 | 0% | 0 | 0 / 0 |
breast | 81% | 434.59 | 372 / 459 | 4% | 2.21 | 46 / 1118 |
adipose | 77% | 372.54 | 924 / 1204 | 0% | 0 | 0 / 0 |
esophagus | 31% | 120.52 | 451 / 1445 | 39% | 46.20 | 72 / 183 |
skin | 45% | 274.85 | 814 / 1809 | 23% | 19.63 | 107 / 472 |
uterus | 49% | 184.35 | 83 / 170 | 16% | 18.68 | 73 / 459 |
liver | 12% | 60.54 | 26 / 226 | 48% | 69.31 | 194 / 406 |
ovary | 43% | 192.33 | 78 / 180 | 3% | 0.90 | 12 / 430 |
eye | 0% | 0 | 0 / 0 | 25% | 12.04 | 20 / 80 |
tonsil | 0% | 0 | 0 / 0 | 20% | 8.79 | 9 / 45 |
blood vessel | 11% | 48.84 | 150 / 1335 | 0% | 0 | 0 / 0 |
muscle | 9% | 27.20 | 70 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0071300 | Biological process | cellular response to retinoic acid |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0045654 | Biological process | positive regulation of megakaryocyte differentiation |
GO_0072659 | Biological process | protein localization to plasma membrane |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0030854 | Biological process | positive regulation of granulocyte differentiation |
GO_0032417 | Biological process | positive regulation of sodium:proton antiporter activity |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0030154 | Biological process | cell differentiation |
GO_0033628 | Biological process | regulation of cell adhesion mediated by integrin |
GO_0050821 | Biological process | protein stabilization |
GO_0015031 | Biological process | protein transport |
GO_0051604 | Biological process | protein maturation |
GO_0001726 | Cellular component | ruffle |
GO_0032587 | Cellular component | ruffle membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0030027 | Cellular component | lamellipodium |
GO_0005634 | Cellular component | nucleus |
GO_0004860 | Molecular function | protein kinase inhibitor activity |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0005509 | Molecular function | calcium ion binding |
GO_0005515 | Molecular function | protein binding |
GO_0019212 | Molecular function | phosphatase inhibitor activity |
Gene name | TESC |
Protein name | Calcineurin B homologous protein 3 (Tescalcin) (TSC) Tescalcin |
Synonyms | CHP3 |
Description | FUNCTION: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. . |
Accessions | E9PQ58 ENST00000462502.5 ENST00000549210.1 ENST00000335209.12 [Q96BS2-1] Q96BS2 ENST00000541210.5 [Q96BS2-3] H0YIX4 ENST00000470612.5 [Q96BS2-2] |