TESC report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TESC at tissue level.

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0045654Biological processpositive regulation of megakaryocyte differentiation
GO_0072659Biological processprotein localization to plasma membrane
GO_0010628Biological processpositive regulation of gene expression
GO_0030854Biological processpositive regulation of granulocyte differentiation
GO_0032417Biological processpositive regulation of sodium:proton antiporter activity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0033628Biological processregulation of cell adhesion mediated by integrin
GO_0050821Biological processprotein stabilization
GO_0015031Biological processprotein transport
GO_0051604Biological processprotein maturation
GO_0001726Cellular componentruffle
GO_0032587Cellular componentruffle membrane
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0019212Molecular functionphosphatase inhibitor activity

IV. Literature review

[source]
Gene nameTESC
Protein nameCalcineurin B homologous protein 3 (Tescalcin) (TSC)
Tescalcin
SynonymsCHP3
DescriptionFUNCTION: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. .

AccessionsE9PQ58
ENST00000462502.5
ENST00000549210.1
ENST00000335209.12 [Q96BS2-1]
Q96BS2
ENST00000541210.5 [Q96BS2-3]
H0YIX4
ENST00000470612.5 [Q96BS2-2]