TEAD4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TEAD4 at tissue level.

III. Associated gene sets

GO_0048568Biological processembryonic organ development
GO_0001708Biological processcell fate specification
GO_0001830Biological processtrophectodermal cell fate commitment
GO_0035329Biological processhippo signaling
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006351Biological processDNA-templated transcription
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0007517Biological processmuscle organ development
GO_0001501Biological processskeletal system development
GO_0007566Biological processembryo implantation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTEAD4
Protein nameTranscriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1)
TEA domain family member 4 isoform 1 (TEA domain family member 4, isoform CRA_b)
TEA domain family member 4 isoform 2
Transcriptional enhancer factor TEF-3
TEA domain family member 4 isoform 1 variant (Transcriptional enhancer factor TEF-3)
TEA domain transcription factor 4
TEA domain family member 4 isoform 3
SynonymshCG_27036
TCF13L1
TEF3
RTEF1
DescriptionFUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. .

AccessionsQ53GI4
H0YGS2
ENST00000358409.7 [Q15561-3]
ENST00000359864
A0A0S2Z4F2
H0Y7B0
ENST00000359864.8 [Q15561-1]
ENST00000443986.3
H0YG62
ENST00000397122.6 [Q15561-2]
A0A0S2Z4E5
H0YFK0
D3DUQ6
ENST00000544666.1
ENST00000543035.6
ENST00000540314.2
Q15561
ENST00000536826.2
H0YFF9
ENST00000358409
A0A0A0MRF3