TBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0007283Biological processspermatogenesis
GO_0006383Biological processtranscription by RNA polymerase III
GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0001188Biological processRNA polymerase I preinitiation complex assembly
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0006352Biological processDNA-templated transcription initiation
GO_0001939Cellular componentfemale pronucleus
GO_0005672Cellular componenttranscription factor TFIIA complex
GO_0000791Cellular componenteuchromatin
GO_0032991Cellular componentprotein-containing complex
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0005668Cellular componentRNA polymerase transcription factor SL1 complex
GO_0001674Cellular componentfemale germ cell nucleus
GO_0005737Cellular componentcytoplasm
GO_0001940Cellular componentmale pronucleus
GO_0001673Cellular componentmale germ cell nucleus
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001091Molecular functionRNA polymerase II general transcription initiation factor binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001046Molecular functioncore promoter sequence-specific DNA binding
GO_0017162Molecular functionaryl hydrocarbon receptor binding
GO_0001093Molecular functionTFIIB-class transcription factor binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0000995Molecular functionRNA polymerase III general transcription initiation factor activity
GO_0001164Molecular functionRNA polymerase I core promoter sequence-specific DNA binding
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0005515Molecular functionprotein binding
GO_0000979Molecular functionRNA polymerase II core promoter sequence-specific DNA binding

IV. Literature review

[source]
Gene nameTBP
Protein nameTATA box binding protein
TATA-box binding protein
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)
SynonymsTFIID
hCG_2029691
GTF2D1
TF2D
DescriptionFUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription . TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) . The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 . The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C . TBP forms the TFIID-A module together with TAF3 and TAF5 . TBP is a general transcription factor that functions at the core of the TFIID complex . During assembly of the core PIC on the promoter, as part of TFIID, TBP binds to and also bends promoter DNA, irrespective of whether the promoter contains a TATA box . Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III . Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC during RNA polymerase I-dependent transcription . The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter . SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA . .

AccessionsENST00000540980.5 [P20226-2]
ENST00000230354.10 [P20226-1]
ENST00000446829.1
ENST00000423353.1
Q6QR78
Q7Z6S5
ENST00000392092.7 [P20226-1]
H0Y6D8
Q6UKI1
ENST00000421512.5
ENST00000636632.1
Q32MN6
P20226
Q32MN7
A0A1B0GVC6
Q7Z6S4