TBCD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007023Biological processpost-chaperonin tubulin folding pathway
GO_0034333Biological processadherens junction assembly
GO_0000278Biological processmitotic cell cycle
GO_0031115Biological processnegative regulation of microtubule polymerization
GO_0007021Biological processtubulin complex assembly
GO_0048667Biological processcell morphogenesis involved in neuron differentiation
GO_0006457Biological processprotein folding
GO_0070830Biological processbicellular tight junction assembly
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0010812Biological processnegative regulation of cell-substrate adhesion
GO_0005874Cellular componentmicrotubule
GO_0005813Cellular componentcentrosome
GO_0005912Cellular componentadherens junction
GO_0016328Cellular componentlateral plasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0048487Molecular functionbeta-tubulin binding
GO_0005096Molecular functionGTPase activator activity
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTBCD
Protein nameTubulin folding cofactor D
Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D)
TBCD protein
Tubulin-specific chaperone D
Tubulin folding cofactor D (Tubulin-specific chaperone D)
SynonymsKIAA0988
PP1096
SSD1
TFCD
DescriptionFUNCTION: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane . Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis . Involved in neuron morphogenesis . .

AccessionsENST00000631706.1
ENST00000683282.1
ENST00000633032.1
A0A804HI57
I3L120
ENST00000572794.1
ENST00000632123.1
ENST00000576760.5
ENST00000355528.9 [Q9BTW9-1]
ENST00000684464.1
A0A804HJ57
ENST00000684349.1
A0A804HLF8
A0A804HL21
ENST00000634094.1
A0A804HI02
ENST00000684408.1
A0A804HJ32
ENST00000632081.1
ENST00000572984.5
A0A0J9YVU1
J3KR97
A0A804HKT8
Q9BTW9
ENST00000683184.1
I3L143
A0A804HJY5
ENST00000684544.1
A0A804HIC0
ENST00000682213.1
A0A804HJL5
ENST00000539345.6
A0A804HKB9
A0A804HL62
ENST00000682722.1
ENST00000684760.1
ENST00000577051.1
A0A804HIU1
I3L3H4
ENST00000576996.5
ENST00000684429.1
ENST00000571712.5
ENST00000633825.1
ENST00000684776.1
A0A804HJU6
A0A804HIN6
A0A0J9YYG2
I3L1S3
A0A804HHW7
ENST00000683444.1
ENST00000682479.1
I6L959
ENST00000572953.5
I3L0V3
I3L439
ENST00000571316.5
I3L163
I3L4D2
A0A0J9YXU4
A0A1J1DRW2
ENST00000684000.1
A0A0J9YVR1
ENST00000574422.1
ENST00000683821.1
I3L131
ENST00000576160.6
ENST00000682654.1
ENST00000633959.1
A0A804HJ99
ENST00000683041.1
I3L1L0
A0A804HK36
ENST00000682315.1
A0A0J9YWI5
A0A804HLI2
ENST00000684188.1
ENST00000684361.1
A0A0J9YY08