Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 24 studies | 32% ± 13% | |
glutamatergic neuron | 8 studies | 35% ± 19% | |
astrocyte | 8 studies | 29% ± 13% | |
oligodendrocyte | 7 studies | 30% ± 8% | |
interneuron | 6 studies | 37% ± 21% | |
macrophage | 6 studies | 26% ± 9% | |
oligodendrocyte precursor cell | 6 studies | 30% ± 10% | |
capillary endothelial cell | 6 studies | 21% ± 4% | |
endothelial cell of lymphatic vessel | 6 studies | 34% ± 12% | |
neuron | 5 studies | 30% ± 11% | |
microglial cell | 5 studies | 29% ± 9% | |
GABAergic neuron | 5 studies | 38% ± 20% | |
epithelial cell | 4 studies | 35% ± 14% | |
lymphocyte | 4 studies | 30% ± 11% | |
fibroblast | 4 studies | 23% ± 8% | |
natural killer cell | 4 studies | 18% ± 2% | |
gamma-delta T cell | 4 studies | 22% ± 9% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 21% ± 5% | |
non-classical monocyte | 3 studies | 23% ± 5% | |
granule cell | 3 studies | 24% ± 3% | |
vein endothelial cell | 3 studies | 44% ± 23% | |
ciliated cell | 3 studies | 24% ± 1% | |
CD8-positive, alpha-beta T cell | 3 studies | 18% ± 2% | |
endothelial cell of vascular tree | 3 studies | 36% ± 20% | |
type II pneumocyte | 3 studies | 20% ± 4% | |
pericyte | 3 studies | 19% ± 4% | |
basal cell | 3 studies | 31% ± 11% | |
transit amplifying cell | 3 studies | 37% ± 23% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 9 studies | 34% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 5276.67 | 21 / 21 | 100% | 23.35 | 504 / 504 |
esophagus | 100% | 4827.87 | 1445 / 1445 | 100% | 18.45 | 183 / 183 |
pancreas | 100% | 2890.88 | 328 / 328 | 100% | 18.56 | 178 / 178 |
prostate | 100% | 6605.52 | 245 / 245 | 100% | 26.34 | 502 / 502 |
stomach | 100% | 4624.98 | 359 / 359 | 100% | 19.40 | 286 / 286 |
lung | 100% | 4970.37 | 578 / 578 | 100% | 22.70 | 1152 / 1155 |
skin | 100% | 4660.15 | 1808 / 1809 | 100% | 28.29 | 471 / 472 |
thymus | 100% | 7694.65 | 653 / 653 | 100% | 32.45 | 603 / 605 |
intestine | 100% | 4782.64 | 966 / 966 | 100% | 20.62 | 525 / 527 |
breast | 100% | 6193.57 | 459 / 459 | 100% | 28.31 | 1113 / 1118 |
brain | 99% | 4606.67 | 2627 / 2642 | 100% | 25.63 | 704 / 705 |
uterus | 100% | 7335.70 | 170 / 170 | 99% | 25.42 | 455 / 459 |
ovary | 100% | 6234.41 | 180 / 180 | 99% | 16.91 | 425 / 430 |
kidney | 100% | 4651.84 | 89 / 89 | 99% | 16.05 | 889 / 901 |
liver | 100% | 2694.88 | 226 / 226 | 99% | 14.17 | 400 / 406 |
adrenal gland | 100% | 4431.35 | 258 / 258 | 95% | 15.62 | 218 / 230 |
adipose | 100% | 5796.19 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 26.67 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 18.43 | 29 / 29 |
spleen | 100% | 6474.15 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 25.21 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 16.48 | 1 / 1 |
heart | 100% | 3693.12 | 860 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4010.74 | 1333 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2850.16 | 799 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 93% | 2691.87 | 861 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007023 | Biological process | post-chaperonin tubulin folding pathway |
GO_0034333 | Biological process | adherens junction assembly |
GO_0000278 | Biological process | mitotic cell cycle |
GO_0031115 | Biological process | negative regulation of microtubule polymerization |
GO_0007021 | Biological process | tubulin complex assembly |
GO_0048667 | Biological process | cell morphogenesis involved in neuron differentiation |
GO_0006457 | Biological process | protein folding |
GO_0070830 | Biological process | bicellular tight junction assembly |
GO_0000226 | Biological process | microtubule cytoskeleton organization |
GO_0010812 | Biological process | negative regulation of cell-substrate adhesion |
GO_0005874 | Cellular component | microtubule |
GO_0005813 | Cellular component | centrosome |
GO_0005912 | Cellular component | adherens junction |
GO_0016328 | Cellular component | lateral plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005923 | Cellular component | bicellular tight junction |
GO_0048487 | Molecular function | beta-tubulin binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0051087 | Molecular function | protein-folding chaperone binding |
GO_0005515 | Molecular function | protein binding |
Gene name | TBCD |
Protein name | Tubulin folding cofactor D Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D) TBCD protein Tubulin-specific chaperone D Tubulin folding cofactor D (Tubulin-specific chaperone D) |
Synonyms | KIAA0988 PP1096 SSD1 TFCD |
Description | FUNCTION: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane . Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis . Involved in neuron morphogenesis . . |
Accessions | ENST00000631706.1 ENST00000683282.1 ENST00000633032.1 A0A804HI57 I3L120 ENST00000572794.1 ENST00000632123.1 ENST00000576760.5 ENST00000355528.9 [Q9BTW9-1] ENST00000684464.1 A0A804HJ57 ENST00000684349.1 A0A804HLF8 A0A804HL21 ENST00000634094.1 A0A804HI02 ENST00000684408.1 A0A804HJ32 ENST00000632081.1 ENST00000572984.5 A0A0J9YVU1 J3KR97 A0A804HKT8 Q9BTW9 ENST00000683184.1 I3L143 A0A804HJY5 ENST00000684544.1 A0A804HIC0 ENST00000682213.1 A0A804HJL5 ENST00000539345.6 A0A804HKB9 A0A804HL62 ENST00000682722.1 ENST00000684760.1 ENST00000577051.1 A0A804HIU1 I3L3H4 ENST00000576996.5 ENST00000684429.1 ENST00000571712.5 ENST00000633825.1 ENST00000684776.1 A0A804HJU6 A0A804HIN6 A0A0J9YYG2 I3L1S3 A0A804HHW7 ENST00000683444.1 ENST00000682479.1 I6L959 ENST00000572953.5 I3L0V3 I3L439 ENST00000571316.5 I3L163 I3L4D2 A0A0J9YXU4 A0A1J1DRW2 ENST00000684000.1 A0A0J9YVR1 ENST00000574422.1 ENST00000683821.1 I3L131 ENST00000576160.6 ENST00000682654.1 ENST00000633959.1 A0A804HJ99 ENST00000683041.1 I3L1L0 A0A804HK36 ENST00000682315.1 A0A0J9YWI5 A0A804HLI2 ENST00000684188.1 ENST00000684361.1 A0A0J9YY08 |