TACC3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TACC3 at tissue level.

III. Associated gene sets

GO_0007091Biological processmetaphase/anaphase transition of mitotic cell cycle
GO_1902850Biological processmicrotubule cytoskeleton organization involved in mitosis
GO_0021987Biological processcerebral cortex development
GO_0060236Biological processregulation of mitotic spindle organization
GO_0051301Biological processcell division
GO_0008283Biological processcell population proliferation
GO_0007052Biological processmitotic spindle organization
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0072686Cellular componentmitotic spindle
GO_0005829Cellular componentcytosol
GO_0034451Cellular componentcentriolar satellite
GO_0000922Cellular componentspindle pole
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTACC3
Protein nameTransforming acidic coiled-coil-containing protein 3 (ERIC-1)
Transforming acidic coiled-coil containing protein 3
Transforming acidic coiled-coil containing protein 3 (Transforming, acidic coiled-coil containing protein 3, isoform CRA_b)
SynonymshCG_18955
ERIC1
DescriptionFUNCTION: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension . May be involved in the control of cell growth and differentiation. May contribute to cancer . .

AccessionsENST00000651817.1
ENST00000470136.2
F8WC55
ENST00000612220.5
ENST00000493975.5
ENST00000458173.4
ENST00000652770.1
A0A494C117
ENST00000651472.1
Q9Y6A5
A0A087WUE2
C9JA91
A0A494BZT8
ENST00000467746.6
E7EMT0
ENST00000313288.9
H0Y8F2