SYNM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031443Biological processfast-twitch skeletal muscle fiber contraction
GO_0045104Biological processintermediate filament cytoskeleton organization
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0042383Cellular componentsarcolemma
GO_0060053Cellular componentneurofilament cytoskeleton
GO_0005912Cellular componentadherens junction
GO_0043034Cellular componentcostamere
GO_0005882Cellular componentintermediate filament
GO_0017166Molecular functionvinculin binding
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0019215Molecular functionintermediate filament binding
GO_0005515Molecular functionprotein binding
GO_0008307Molecular functionstructural constituent of muscle

IV. Literature review

[source]
Gene nameSYNM
Protein nameSynemin
Desmuslin, isoform CRA_a (Synemin)
Synemin (Desmuslin)
SynonymsSYN
DMN
hCG_28262
KIAA0353
DescriptionFUNCTION: Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. .

AccessionsA0A075B7B1
ENST00000594047.2 [O15061-2]
ENST00000594047
ENST00000560674.5
H0YL34
C9JIE4
ENST00000328642.11 [O15061-3]
O15061
ENST00000336292.11 [O15061-1]
ENST00000328642