SUPT6H report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010793Biological processregulation of mRNA export from nucleus
GO_0006397Biological processmRNA processing
GO_0140673Biological processtranscription elongation-coupled chromatin remodeling
GO_0051028Biological processmRNA transport
GO_0051147Biological processregulation of muscle cell differentiation
GO_0050684Biological processregulation of mRNA processing
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0045191Biological processregulation of isotype switching
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0008380Biological processRNA splicing
GO_0001825Biological processblastocyst formation
GO_0034728Biological processnucleosome organization
GO_0008023Cellular componenttranscription elongation factor complex
GO_0005654Cellular componentnucleoplasm
GO_0003677Molecular functionDNA binding
GO_0042393Molecular functionhistone binding
GO_0003723Molecular functionRNA binding
GO_0031491Molecular functionnucleosome binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSUPT6H
Protein nameSPT6 homolog, histone chaperone and transcription elongation factor
Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)
Alternative protein SUPT6H
SynonymsSPT6H
KIAA0162
DescriptionFUNCTION: Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. .

AccessionsENST00000584312.1
L8E7F9
ENST00000314616.11 [Q7KZ85-1]
Q7KZ85
ENST00000347486.8 [Q7KZ85-1]
K7EK85
J3QS64
ENST00000577713.1