Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 25% ± 8% | |
monocyte | 7 studies | 17% ± 3% | |
classical monocyte | 7 studies | 21% ± 6% | |
myeloid cell | 6 studies | 20% ± 4% | |
macrophage | 6 studies | 24% ± 6% | |
epithelial cell | 5 studies | 35% ± 14% | |
natural killer cell | 4 studies | 19% ± 1% | |
non-classical monocyte | 4 studies | 21% ± 8% | |
glutamatergic neuron | 4 studies | 42% ± 19% | |
CD8-positive, alpha-beta T cell | 4 studies | 17% ± 1% | |
plasmacytoid dendritic cell | 4 studies | 21% ± 7% | |
basal cell | 4 studies | 25% ± 9% | |
astrocyte | 4 studies | 27% ± 8% | |
dendritic cell | 4 studies | 28% ± 13% | |
hematopoietic precursor cell | 3 studies | 23% ± 3% | |
microglial cell | 3 studies | 26% ± 2% | |
fibroblast | 3 studies | 21% ± 6% | |
ciliated cell | 3 studies | 22% ± 7% | |
lymphocyte | 3 studies | 23% ± 2% | |
secretory cell | 3 studies | 19% ± 2% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 17% ± 1% | |
GABAergic neuron | 3 studies | 39% ± 13% | |
oligodendrocyte precursor cell | 3 studies | 26% ± 6% | |
endothelial cell of lymphatic vessel | 3 studies | 20% ± 4% | |
gamma-delta T cell | 3 studies | 23% ± 9% | |
goblet cell | 3 studies | 30% ± 16% | |
neuron | 3 studies | 25% ± 9% | |
oligodendrocyte | 3 studies | 24% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 9565.21 | 1445 / 1445 | 100% | 63.21 | 183 / 183 |
liver | 100% | 6082.31 | 226 / 226 | 100% | 32.25 | 406 / 406 |
pancreas | 100% | 5496.77 | 328 / 328 | 100% | 45.02 | 178 / 178 |
prostate | 100% | 9957.54 | 245 / 245 | 100% | 47.81 | 502 / 502 |
skin | 100% | 10807.08 | 1809 / 1809 | 100% | 64.13 | 472 / 472 |
thymus | 100% | 10064.53 | 653 / 653 | 100% | 46.81 | 605 / 605 |
breast | 100% | 9546.10 | 459 / 459 | 100% | 60.03 | 1116 / 1118 |
intestine | 100% | 10457.36 | 966 / 966 | 100% | 40.56 | 526 / 527 |
stomach | 100% | 7990.82 | 359 / 359 | 100% | 44.24 | 285 / 286 |
brain | 100% | 6574.49 | 2636 / 2642 | 100% | 51.70 | 704 / 705 |
bladder | 100% | 10354.62 | 21 / 21 | 100% | 44.57 | 502 / 504 |
uterus | 100% | 9774.81 | 170 / 170 | 100% | 47.31 | 457 / 459 |
lung | 100% | 9454.40 | 578 / 578 | 99% | 47.72 | 1147 / 1155 |
kidney | 100% | 7431.82 | 89 / 89 | 99% | 41.79 | 892 / 901 |
ovary | 100% | 9750.14 | 180 / 180 | 98% | 28.93 | 422 / 430 |
adrenal gland | 100% | 10203.29 | 258 / 258 | 97% | 45.82 | 223 / 230 |
adipose | 100% | 9489.30 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 10229.45 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 69.18 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 49.13 | 29 / 29 |
muscle | 100% | 10132.60 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 10975.14 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 48.31 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.54 | 1 / 1 |
peripheral blood | 98% | 7797.49 | 913 / 929 | 0% | 0 | 0 / 0 |
heart | 98% | 5728.36 | 846 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0010793 | Biological process | regulation of mRNA export from nucleus |
GO_0006397 | Biological process | mRNA processing |
GO_0140673 | Biological process | transcription elongation-coupled chromatin remodeling |
GO_0051028 | Biological process | mRNA transport |
GO_0051147 | Biological process | regulation of muscle cell differentiation |
GO_0050684 | Biological process | regulation of mRNA processing |
GO_0006368 | Biological process | transcription elongation by RNA polymerase II |
GO_0045191 | Biological process | regulation of isotype switching |
GO_0032968 | Biological process | positive regulation of transcription elongation by RNA polymerase II |
GO_0008380 | Biological process | RNA splicing |
GO_0001825 | Biological process | blastocyst formation |
GO_0034728 | Biological process | nucleosome organization |
GO_0008023 | Cellular component | transcription elongation factor complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0003677 | Molecular function | DNA binding |
GO_0042393 | Molecular function | histone binding |
GO_0003723 | Molecular function | RNA binding |
GO_0031491 | Molecular function | nucleosome binding |
GO_0005515 | Molecular function | protein binding |
Gene name | SUPT6H |
Protein name | SPT6 homolog, histone chaperone and transcription elongation factor Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) Alternative protein SUPT6H |
Synonyms | SPT6H KIAA0162 |
Description | FUNCTION: Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. . |
Accessions | ENST00000584312.1 L8E7F9 ENST00000314616.11 [Q7KZ85-1] Q7KZ85 ENST00000347486.8 [Q7KZ85-1] K7EK85 J3QS64 ENST00000577713.1 |