STXBP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0008286Biological processinsulin receptor signaling pathway
GO_1902808Biological processpositive regulation of cell cycle G1/S phase transition
GO_0061178Biological processregulation of insulin secretion involved in cellular response to glucose stimulus
GO_0099072Biological processregulation of postsynaptic membrane neurotransmitter receptor levels
GO_0010838Biological processpositive regulation of keratinocyte proliferation
GO_0050821Biological processprotein stabilization
GO_0071346Biological processcellular response to type II interferon
GO_0006605Biological processprotein targeting
GO_0010827Biological processregulation of glucose transmembrane transport
GO_0070062Cellular componentextracellular exosome
GO_0045335Cellular componentphagocytic vesicle
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005515Molecular functionprotein binding
GO_0019905Molecular functionsyntaxin binding

IV. Literature review

[source]
Gene nameSTXBP4
Protein nameSyntaxin binding protein 4
Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)
STXBP4 protein
Synonyms
DescriptionFUNCTION: Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). .

AccessionsENST00000376352.6 [Q6ZWJ1-1]
E7EPP7
ENST00000463234.1
ENST00000398391.6 [Q6ZWJ1-2]
Q08AL9
Q6ZWJ1
B5MCT9
ENST00000434978.6
K7ESN8
ENST00000405898.5