STN1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of STN1 at tissue level.

III. Associated gene sets

GO_0032211Biological processnegative regulation of telomere maintenance via telomerase
GO_0016233Biological processtelomere capping
GO_0045740Biological processpositive regulation of DNA replication
GO_0010833Biological processtelomere maintenance via telomere lengthening
GO_0000723Biological processtelomere maintenance
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_1990879Cellular componentCST complex
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0005634Cellular componentnucleus
GO_0043047Molecular functionsingle-stranded telomeric DNA binding
GO_0042162Molecular functiontelomeric DNA binding
GO_0005515Molecular functionprotein binding
GO_0003697Molecular functionsingle-stranded DNA binding

IV. Literature review

[source]
Gene nameSTN1
Protein nameSTN1 subunit of CST complex
CST complex subunit STN1 (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog)
SynonymsOBFC1
DescriptionFUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation . However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha . The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins . Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres . Promotes general replication start following replication-fork stalling implicating new origin firing . May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication . .; FUNCTION: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. .

FUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. .

FUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. .

FUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. .

AccessionsA0A8V8TNB0
ENST00000698301.1
A0A8V8TNE0
ENST00000698297.1
ENST00000698243.1
A0A8V8TM56
ENST00000698328.1
ENST00000466828.6
ENST00000698298.1
ENST00000698241.1
ENST00000698246.1
ENST00000698305.1
A0A8V8TN12
A0A8V8TLN6
ENST00000698245.1
A0A8V8TLL1
ENST00000698300.1
ENST00000224950.8
A0A8V8TNE6
Q9H668
A0A8V8TN42
ENST00000369764.2
ENST00000698304.1
A0A8V8TM23
A0A8V8TM51
ENST00000698299.1
ENST00000698242.1
ENST00000698302.1
ENST00000472951.1
ENST00000698303.1