ST8SIA4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097503Biological processsialylation
GO_0001574Biological processganglioside biosynthetic process
GO_0036211Biological processprotein modification process
GO_0007399Biological processnervous system development
GO_0009311Biological processoligosaccharide metabolic process
GO_0006491Biological processN-glycan processing
GO_0006486Biological processprotein glycosylation
GO_0000139Cellular componentGolgi membrane
GO_0005576Cellular componentextracellular region
GO_0005794Cellular componentGolgi apparatus
GO_0003828Molecular functionalpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO_0008373Molecular functionsialyltransferase activity
GO_0033691Molecular functionsialic acid binding

IV. Literature review

[source]
Gene nameST8SIA4
Protein nameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV)
SynonymsPST
PST1
SIAT8D
DescriptionFUNCTION: Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages . Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG . It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid . .

AccessionsENST00000523381.1
Q92187
ENST00000231461.10 [Q92187-1]
ENST00000451528.2 [Q92187-2]
E5RFK3