Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 19 studies | 27% ± 13% | |
| B cell | 11 studies | 20% ± 5% | |
| dendritic cell | 10 studies | 34% ± 10% | |
| microglial cell | 10 studies | 41% ± 13% | |
| classical monocyte | 9 studies | 21% ± 6% | |
| natural killer cell | 8 studies | 20% ± 5% | |
| non-classical monocyte | 8 studies | 23% ± 8% | |
| conventional dendritic cell | 8 studies | 21% ± 6% | |
| monocyte | 7 studies | 26% ± 8% | |
| endothelial cell | 7 studies | 24% ± 10% | |
| myeloid cell | 7 studies | 23% ± 4% | |
| CD8-positive, alpha-beta T cell | 7 studies | 20% ± 2% | |
| mononuclear phagocyte | 6 studies | 20% ± 6% | |
| interneuron | 6 studies | 25% ± 9% | |
| regulatory T cell | 6 studies | 18% ± 2% | |
| GABAergic neuron | 6 studies | 33% ± 11% | |
| T cell | 5 studies | 20% ± 5% | |
| CD16-negative, CD56-bright natural killer cell, human | 5 studies | 22% ± 5% | |
| ciliated cell | 5 studies | 18% ± 4% | |
| memory B cell | 4 studies | 16% ± 1% | |
| lymphocyte | 4 studies | 26% ± 8% | |
| glutamatergic neuron | 4 studies | 38% ± 12% | |
| CD8-positive, alpha-beta memory T cell | 4 studies | 19% ± 3% | |
| plasmablast | 3 studies | 31% ± 14% | |
| neuron | 3 studies | 28% ± 6% | |
| plasma cell | 3 studies | 30% ± 8% | |
| CD16-positive, CD56-dim natural killer cell, human | 3 studies | 18% ± 1% | |
| effector memory CD8-positive, alpha-beta T cell | 3 studies | 18% ± 1% | |
| tissue-resident macrophage | 3 studies | 22% ± 5% | |
| leukocyte | 3 studies | 30% ± 8% | |
| mast cell | 3 studies | 23% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 99% | 597.68 | 647 / 653 | 99% | 10.94 | 596 / 605 |
| breast | 99% | 686.74 | 455 / 459 | 96% | 7.17 | 1070 / 1118 |
| lung | 100% | 1360.52 | 578 / 578 | 94% | 11.97 | 1080 / 1155 |
| brain | 77% | 305.03 | 2029 / 2642 | 89% | 7.27 | 627 / 705 |
| esophagus | 71% | 182.03 | 1023 / 1445 | 78% | 4.51 | 142 / 183 |
| uterus | 79% | 236.21 | 134 / 170 | 68% | 4.00 | 311 / 459 |
| intestine | 86% | 523.80 | 835 / 966 | 60% | 3.01 | 314 / 527 |
| bladder | 76% | 315.33 | 16 / 21 | 68% | 4.39 | 344 / 504 |
| stomach | 69% | 182.98 | 248 / 359 | 72% | 4.42 | 207 / 286 |
| kidney | 49% | 135.45 | 44 / 89 | 76% | 18.35 | 688 / 901 |
| adrenal gland | 76% | 216.05 | 197 / 258 | 47% | 3.56 | 108 / 230 |
| prostate | 80% | 247.85 | 197 / 245 | 35% | 1.20 | 174 / 502 |
| pancreas | 21% | 51.66 | 68 / 328 | 88% | 5.71 | 157 / 178 |
| skin | 41% | 96.04 | 742 / 1809 | 66% | 5.07 | 313 / 472 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 23.58 | 29 / 29 |
| spleen | 100% | 2275.69 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 3345.86 | 928 / 929 | 0% | 0 | 0 / 0 |
| adipose | 100% | 925.47 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 24% | 54.09 | 43 / 180 | 75% | 4.43 | 322 / 430 |
| heart | 86% | 273.63 | 742 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 75% | 341.17 | 1006 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 71% | 4.73 | 32 / 45 |
| liver | 34% | 75.15 | 77 / 226 | 33% | 1.36 | 132 / 406 |
| muscle | 24% | 48.01 | 196 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.33 | 7 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0097503 | Biological process | sialylation |
| GO_0001574 | Biological process | ganglioside biosynthetic process |
| GO_0036211 | Biological process | protein modification process |
| GO_0007399 | Biological process | nervous system development |
| GO_0009311 | Biological process | oligosaccharide metabolic process |
| GO_0006491 | Biological process | N-glycan processing |
| GO_0006486 | Biological process | protein glycosylation |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0003828 | Molecular function | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity |
| GO_0008373 | Molecular function | sialyltransferase activity |
| GO_0033691 | Molecular function | sialic acid binding |
| Gene name | ST8SIA4 |
| Protein name | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV) |
| Synonyms | PST PST1 SIAT8D |
| Description | FUNCTION: Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages . Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG . It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid . . |
| Accessions | ENST00000523381.1 Q92187 ENST00000231461.10 [Q92187-1] ENST00000451528.2 [Q92187-2] E5RFK3 |