ST3GAL6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071354Biological processcellular response to interleukin-6
GO_0009312Biological processoligosaccharide biosynthetic process
GO_0009247Biological processglycolipid biosynthetic process
GO_0018146Biological processkeratan sulfate biosynthetic process
GO_0006486Biological processprotein glycosylation
GO_0000139Cellular componentGolgi membrane
GO_0070062Cellular componentextracellular exosome
GO_0016020Cellular componentmembrane
GO_0008373Molecular functionsialyltransferase activity
GO_0003836Molecular functionbeta-galactoside (CMP) alpha-2,3-sialyltransferase activity

IV. Literature review

[source]
Gene nameST3GAL6
Protein nameType 2 lactosamine alpha-2,3-sialyltransferase (EC 2.4.99.-) (CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI) (ST3Gal VI) (ST3GalVI) (Sialyltransferase 10)
Type 2 lactosamine alpha-2,3-sialyltransferase (CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI) (ST3Gal VI) (Sialyltransferase 10)
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
SynonymsSIAT10
hCG_18894
DescriptionFUNCTION: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.

FUNCTION: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1. .

AccessionsA0A087WXB8
ENST00000394162.5 [Q9Y274-1]
C9JWJ3
ENST00000460774.5
F2Z2F4
C9IZL6
ENST00000468553.5
ENST00000486334.6
ENST00000492254.6
ENST00000485145.1
ENST00000613264
ENST00000483910.6 [Q9Y274-1]
ENST00000613264.5 [Q9Y274-1]
ENST00000497008.5
ENST00000265261.11 [Q9Y274-1]
ENST00000476833.5
Q9Y274
ENST00000486249.5
C9J480
C9J0E2
C9JMW7
C9JWI9
C9J9Y4
ENST00000495376.5
ENST00000469105.5
ENST00000485391.5