SPTY2D1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006355Biological processregulation of DNA-templated transcription
GO_0031507Biological processheterochromatin formation
GO_0006334Biological processnucleosome assembly
GO_0006360Biological processtranscription by RNA polymerase I
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0003677Molecular functionDNA binding
GO_0042393Molecular functionhistone binding
GO_0140713Molecular functionhistone chaperone activity
GO_0001042Molecular functionRNA polymerase I core binding

IV. Literature review

[source]
Gene nameSPTY2D1
Protein nameProtein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1)
Synonyms
DescriptionFUNCTION: Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin . Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription . Binds DNA and histones and promotes nucleosome assembly (in vitro) . Facilitates formation of tetrameric histone complexes containing histone H3 and H4 . Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA . .

AccessionsQ68D10
ENST00000336349.6 [Q68D10-1]