SPTLC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0006686Biological processsphingomyelin biosynthetic process
GO_1904504Biological processpositive regulation of lipophagy
GO_0060612Biological processadipose tissue development
GO_0046512Biological processsphingosine biosynthetic process
GO_0046513Biological processceramide biosynthetic process
GO_0046511Biological processsphinganine biosynthetic process
GO_0017059Cellular componentserine palmitoyltransferase complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004758Molecular functionserine C-palmitoyltransferase activity
GO_0030170Molecular functionpyridoxal phosphate binding

IV. Literature review

[source]
Gene nameSPTLC2
Protein nameSerine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)
Alternative protein SPTLC2
Serine palmitoyltransferase long chain base subunit 2
SynonymsLCB2
KIAA0526
DescriptionFUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases . The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core . The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference . The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA . The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference . Crucial for adipogenesis (By similarity). .

AccessionsH0YJ96
H0YJV2
ENST00000556607.1
L8E997
ENST00000216484.7
ENST00000554901.1
O15270