SPTLC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046511Biological processsphinganine biosynthetic process
GO_0030148Biological processsphingolipid biosynthetic process
GO_0006686Biological processsphingomyelin biosynthetic process
GO_1904504Biological processpositive regulation of lipophagy
GO_1904649Biological processregulation of fat cell apoptotic process
GO_0046512Biological processsphingosine biosynthetic process
GO_0046513Biological processceramide biosynthetic process
GO_0006665Biological processsphingolipid metabolic process
GO_0017059Cellular componentserine palmitoyltransferase complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding
GO_0004758Molecular functionserine C-palmitoyltransferase activity
GO_0030170Molecular functionpyridoxal phosphate binding

IV. Literature review

[source]
Gene nameSPTLC1
Protein nameSerine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)
Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (Serine-palmitoyl-CoA transferase 1)
Alternative protein SPTLC1
Serine palmitoyltransferase long chain base subunit 1
SynonymsLCB1
DescriptionFUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core . The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference . The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA . The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference . Required for adipocyte cell viability and metabolic homeostasis (By similarity). .

AccessionsENST00000689401.1
L8E7V1
A0A2R8Y4S0
ENST00000692363.1
ENST00000642671.1
ENST00000687817.1
ENST00000646481.1
A0A8I5KWE0
ENST00000643599.1
ENST00000687427.1
ENST00000337841.4 [O15269-2]
Q6NUL7
ENST00000686600.1
ENST00000689423.1
A0A2R8Y763
A0A8I5KUM4
ENST00000644140.1
A0A2R8Y6A2
A0A8I5QJP4
ENST00000690139.1 [O15269-2]
ENST00000461132.2
ENST00000646534.1
ENST00000687972.1
ENST00000488921.6
ENST00000693147.1
ENST00000262554.7 [O15269-1]
A0A8I5QKQ8
O15269