SPRED1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090051Biological processnegative regulation of cell migration involved in sprouting angiogenesis
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0060979Biological processvasculogenesis involved in coronary vascular morphogenesis
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0043517Biological processpositive regulation of DNA damage response, signal transduction by p53 class mediator
GO_0016525Biological processnegative regulation of angiogenesis
GO_0010801Biological processnegative regulation of peptidyl-threonine phosphorylation
GO_1902747Biological processnegative regulation of lens fiber cell differentiation
GO_0090311Biological processregulation of protein deacetylation
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0043409Biological processnegative regulation of MAPK cascade
GO_0043408Biological processregulation of MAPK cascade
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005901Cellular componentcaveola
GO_0030291Molecular functionprotein serine/threonine kinase inhibitor activity
GO_0019901Molecular functionprotein kinase binding
GO_0019902Molecular functionphosphatase binding
GO_0005173Molecular functionstem cell factor receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPRED1
Protein nameAlternative protein SPRED1
Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)
Sprouty related EVH1 domain containing 1
Synonyms
DescriptionFUNCTION: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin . Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). .

AccessionsH0YMN8
ENST00000561317.1
L8EBE5
Q7Z699
ENST00000299084.9